The purpose of this study is to evaluate the safety and efficacy of a quadruple regimen (VX-222, telaprevir, pegylated interferon, and ribavirin)in subjects with hepatitis C with cirrhosis.

Inclusion Criteria:

• Subjects must have genotype 1 Chronic Hepatitis C
• Subjects must have compensated cirrhosis
• Subjects may either be treatment naïve, or may have received a course of Peg IFN/RBV without evidence of response. Subjects who are considered to be relapsers to Peg IFN/RBV, or who are partial or null responders will be considered
• Subjects with hemophilia may be permitted to enroll with permission of the medical monitor

Exclusion Criteria:

• Any previous treatment with an investigational drug or drug regimen for the treatment of hepatitis C, or previous treatment with an approved protease inhibitor
• Any contraindication to Peg-IFN or RBV therapy
• Evidence of hepatic decompensation: history of ascites, hepatic encephalopathy, or bleeding esophageal varices
• A history of acquired immunodeficiency infection, organ transplantation or have an ongoing requirement for immunosuppressive medicines