Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators administered different kinds of colloids before transfusion of red blood cell to patient undergoing total hip replacement arthroplasty. The investigators will compare the differences of changes in rotational thromboelastometry (ROTEM) data among them.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PENTA group | Active Comparator | Pentaspan is administered as a colloid. |
|
| voluVEN group | Active Comparator | Voluven is administered as a colloid. |
|
| voluLYTE group | Active Comparator | Volulyte is administered as a colloid. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pentaspan, voluven, volulyte | Drug | Different colloids are administered during operation for replacement of blood loss before the transfusion of blood. |
|
| Measure | Description | Time Frame |
|---|---|---|
| INTEM parameters change from preoperative values at post-operation | clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm) | 30 minutes before operation and 30 minutes after operation |
| EXTEM parameters change from preoperative values at post-operation | clotting time (sec), clot firmness time (sec), alpah angle, maximum clot firmness (mm) | 30 minutes before and 30 minutes after operation. |
| FIBTEM parameters change from preoperative values at post-operation | maximum clot firmness (mm) | 30 min before and 30 min after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Infused total fluid volume | crystalloid and colloid | Participants will be followed for the duration of THRA operation in operating room, an expected average tiem of 3 hours |
| Hemoglobin | 30 minutes before operation and 30 minutes after operation |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam | Gyounggi | 463-707 | South Korea |
Not provided
| ID | Term |
|---|---|
| D006895 | Hydroxyethyl Starch Derivatives |
| C485123 | HES 130-0.4 |
| ID | Term |
|---|---|
| D013213 | Starch |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005936 | Glucans |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| postoperative blood loss | postoperative 1 day and 2 day |
| Hematocrit | 30 minutes before operation and 30 minutes after operation |
| Platelet | 30 minutes before operation and 30 minutes after operation |
| Prothrombin Time-Internatiolnal Normalized Ratio | 30 minutes before operation and 30 minutes after operation |
| Activated Partial Thrombin Time | 30 minutes before operation and 30 minutes after operation |
| electrolytes | 30 minutes before operation and 30 minutes after operation |
| D011134 |
| Polysaccharides |