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| ID | Type | Description | Link |
|---|---|---|---|
| 48024 | Other Grant/Funding Number | Consejo Nacional de Ciencia y Tecnología (CONACYT)/216324 |
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We evaluated the effect of two weeks of intensive supervised physical activity in serum fibroblast growth factor 21 (FGF21) levels.
Comparative and longitudinal study. Anthropometric and biochemical evaluation were done before, 1hr and 4hr after a bout of exercise and repeated after two weeks of daily supervised exercise. We studied sedentary young healthy women. A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks. The Department of Endocrinology and Metabolism at the INCMNSZ performed all biochemical laboratory measurements using standardized procedures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supervised exercising | Experimental | A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supervised Exercising | Other | A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks | Serum measurement of FGF21 using human ELISA kit was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline Free Fatty Acids (FFAs) Acutely and at Two Weeks | Serum measurement of free fatty acids (FFAs) was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Cuevas-Ramos, MD | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Principal Investigator |
| Paloma Almeda-Valdes, MD | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Principal Investigator |
| Carlos A Aguilar-Salinas, MD | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| INCMNSZ | Mexico City | Tlalpan | 14000 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20566587 | Background | Cuevas-Ramos D, Almeda-Valdes P, Gomez-Perez FJ, Meza-Arana CE, Cruz-Bautista I, Arellano-Campos O, Navarrete-Lopez M, Aguilar-Salinas CA. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Eur J Endocrinol. 2010 Sep;163(3):469-77. doi: 10.1530/EJE-10-0454. Epub 2010 Jun 21. | |
| 11991917 |
| Label | URL |
|---|---|
| INCMNSZ | View source |
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In the initial visit, patients were instructed to keep unaltered their diet, lifestyle and physical activity. Basal daily physical activity was evaluated with a questionnaire. All participants were assigned to the intervention group. All subjects underwent basal and final physical and biochemical evaluation.
From March 2010 to August 2011 a total of 60 sedentary young women without contraindication for exercising were included. Study was carried out at Department of Endocrinology, Cardiology and Internal Medicine of the INCMNSZ.
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| ID | Title | Description |
|---|---|---|
| FG000 | Supervised Exercising | A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Supervised Exercising | A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks | Serum measurement of FGF21 using human ELISA kit was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report, we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. All participants were analyzed. | Posted | Median | Inter-Quartile Range | ng/L | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
|
Adverse events were supervised throughout every treadmill test.
Continuous electrocardiographic monitoring were registered in every treadmill test.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Supervised Exercising | A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants. |
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We cannot fully control other potential sources of physical activity. The results may not be applicable to men. We did not register the caloric consumption during the study.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Daniel Cuevas-Ramos | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 525554870900 | 2407 | shiverqks@hotmail.com |
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| ID | Term |
|---|---|
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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|
| Change From Baseline Epinephrine Acutely and at Two Weeks | Serum measurement of epinephrine was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
| Change From Baseline Leptin Acutely and at Two Weeks | Serum measurement of leptin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
| Change From Baseline Total Adiponectin Acutely and at Two Weeks | Serum measurement of total adiponectin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
| Change From Baseline Fasting Glucose Acutely and at Two Weeks | Serum measurement of glucose was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
| Background |
| Hill J, Timmis A. Exercise tolerance testing. BMJ. 2002 May 4;324(7345):1084-7. doi: 10.1136/bmj.324.7345.1084. No abstract available. |
| 22701542 | Derived | Cuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, Mehta R, Oseguera-Moguel J, Aguilar-Salinas CA. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One. 2012;7(5):e38022. doi: 10.1371/journal.pone.0038022. Epub 2012 May 31. |
| Participants |
|
| Age Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
|
|
| Secondary | Change From Baseline Free Fatty Acids (FFAs) Acutely and at Two Weeks | Serum measurement of free fatty acids (FFAs) was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report, we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. | Posted | Median | Inter-Quartile Range | mg/dL | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
|
|
|
| Secondary | Change From Baseline Epinephrine Acutely and at Two Weeks | Serum measurement of epinephrine was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise. | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report (5), we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. | Posted | Median | Inter-Quartile Range | pg/mL | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
|
|
|
| Secondary | Change From Baseline Leptin Acutely and at Two Weeks | Serum measurement of leptin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report, we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. | Posted | Median | Inter-Quartile Range | ng/mL | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
|
|
|
| Secondary | Change From Baseline Total Adiponectin Acutely and at Two Weeks | Serum measurement of total adiponectin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report, we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. | Posted | Median | Inter-Quartile Range | ng/mL | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
|
|
|
| Secondary | Change From Baseline Fasting Glucose Acutely and at Two Weeks | Serum measurement of glucose was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise | The sample size was calculated using the formula for means for two-tailed comparisons. According to our previous report, we expected a minimal change of 80 ng/l of FGF21 after two weeks of physical activity. Using a SD of 160 ng/l with an alfa of 0.05 and a study power of 80%, a total of 60 subjects were calculated. | Posted | Mean | Standard Deviation | mg/dL | Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise |
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| 0 |
| 60 |
| 0 |
| 60 |
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