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Colonoscopy is a basic but important tool to diagnose and treat lesions of the colon. Proper colon cleansing is essential for colonoscopy to be performed with a good quality. Inadequate bowel preparation leads to longer colonoscopic insertion time and patient discomfort, as well as inadequate diagnostic yield of colonic lesions. Frequency of colonoscopy failure due to bad bowel preparation is reported to be 0.3% to 6.5 percent, and the rate increases with liver cirrhosis, constipation, dementia, stroke, or administration of tricyclic antidepressants. In case of colonoscopy failure due to bad bowel preparation, the second colonoscopy can be performed with either adding a colon cleansing solution immediately, or it can be performed after a few days with colon cleansing agent together with prokinetics. These different kinds of bowel preparations after first colonoscopy failure have not been compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PEG | Active Comparator | 2L of polyethylene glycol addition immediately after first colonoscopy failure |
|
| PEG + bisacodyl | Experimental | One week after initial colonoscopy failure, conventional amount (5L) of polyethylene glycol together with bisacodyl administration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| polyethylene glycol, Bisacodyl | Drug | After failure of first colonoscopy, bowel preparation with polyethylene glycol and bisacodyl one week after |
|
| Measure | Description | Time Frame |
|---|---|---|
| second colonoscopy failure due to inadequate bowel preparation (PEG+bisdacodyl group) | one week | |
| second colonoscopy failure due to inadequate bowel preparation (PEG group) | within the same day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeong-Sik Byeon, MD, PhD | Asan Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | 138-736 | South Korea |
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| ID | Term |
|---|---|
| D011092 | Polyethylene Glycols |
| D001726 | Bisacodyl |
| ID | Term |
|---|---|
| D005026 | Ethylene Glycols |
| D006018 | Glycols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| polyethylene glycol | Drug | Immediately after first colonoscopy failure, polyethylene glycol 2L addition |
|
| D011108 |
| Polymers |
| D046911 | Macromolecular Substances |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D003408 | Cresols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |