Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis

An Double-blind, Active-controlled, Parallel-group, Randomized, Multi-center Study to Compare Efficacy and Safety of LBSA0103 Once Versus Hyruan Plus Injection Once Weekly for 3weeks in the Treatment of Patients With Osteoarthritis of the Knee

The purpose of this study is to compare efficacy and safety of intra-articular LBSA0103 once versus intra-articular hyaluronic acid injections (Hyruan Plus Injection) once weekly for 3 weeks in the treatment of patients with osteoarthritis of the knee.

Inclusion Criteria:

• Over 40 years of age
• Kellgren & Lawrence grade I-III
• If there is more than one knee having a weight bearing pain of at least 40mm evaluated by 100mm VAS
• Be willing to discontinue all nonsteroidal anti-inflammatory drugs(NSAIDs), analgesics, condroichin sulfate/glucosamine or physical therapy for the duration of the study

Exclusion Criteria:

• Body mass index > 32
• Have rheumarthritis
• Patients who have a weight-bearing pain of less than 40mm on both knees when measured by 100mm-VAS
• Have Sudek's atrophy, Paget's disease, Spinal disc herniation
• Kellgren & Lawrence Grade IV