Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma

Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma: a Multicentric Study

Patients with Multiple Myeloma (MM) are at increased risk of venous thromboembolic event, especially in newly diagnosed patients and during induction treatment with thalidomide in combination with dexamethasone. This association was mainly heightened during the 3 first months of chemotherapy.

Several coagulation abnormalities have been described. Laboratory tests measuring the overall thrombophilic tendency might be useful to assess thrombosis risk.

The aim of this study is to compare thrombin generation by calibrated automated thrombogram during the 3 first cycles of chemotherapy in patients with newly diagnosed MM.

Inclusion Criteria:

• Inscription to medical assurance
• Patients who gave their written consent
• Patients with newly diagnosed Multiple Myeloma required chemotherapy

Exclusion Criteria:

• Patients with renal failure who need to undergo hemodialysis
• Patients with indication for curative anticoagulant therapy
• Patient with 3 month follow-up not possible
• Patient with life expectancy < 6 month