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This study is a prospective randomized clinical trial to compare the efficacy of the urinary and recombinant hCG on oocyte quality for ovulation induction in women undergoing IVF/ICSI.
The study population comprised of all infertile patients aged 20-37 years which underwent of in-vitro fertilization in royan institute, Tehran Iran.
In this study all patients were treated with a long stimulation protocol in which GnRH-analogue (Buserelin subcutaneous, 0.5cc daily) was given as a pre-treatment and recombinant FSH (rFSH) administration was started when pituitary desensitization was confirmed. From the 7th day of stimulation in both groups, daily monitoring of follicle size by ultrasound was performed and the dose of rFSH was adjusted according to the response of each patient. When at least two follicles > 18 mm diameter were seen, ovulation was triggered with hCG and patients allocated into three different study groups as per the following:
Data collection will be performed by using questionnaire to be filled as per the available records and laboratory results. Data analysis will be done through descriptive and perceptive statistical methods by using SPSS software version 16 for windows.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A: recombinant hCG(250 µg Ovitrell) | Experimental | 1- Group A consisted of 60 infertile women who received recombinant hCG(250 µg Ovitrelle) |
|
| B: recombinant hCG(500 µg Ovitrell) | Experimental | 2- Group B consisted of 60 infertile women who received recombinant hCG(500 µg Ovitrelle) |
|
| C: urinary hCG | Experimental | 3- Group C consisted of 60 infertile patients received 10,000 IU urinary hCG |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| recombinant hCG | Drug | recombinant hCG(250 µg Ovitrell) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of mature oocytes | evaluation the effect of recombinant hcg on number of oocytes up to 1 hour after oocytes retrieval | Up to1 hour after oocyte retrieval |
| Measure | Description | Time Frame |
|---|---|---|
| number of retrieved oocytes per number of aspirated follicles proportion | Evaluation the effect of recombinant hCG to retrieve oocytes per number of aspirated follicles proportion | up to 1 hour after oocyte retrieval |
| fertilization rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hamid Gourabi, PhD | Head of Royan Institute | Study Chair |
| Taraneh Madani, MD | gynecology scientist | Study Director |
| Ladan Mohmmadi yeganeh, MSc | Investigator | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royan Institute | Tehran | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23274511 | Derived | Madani T, Mohammadi Yeganeh L, Ezabadi Z, Hasani F, Chehrazi M. Comparing the efficacy of urinary and recombinant hCG on oocyte/follicle ratio to trigger ovulation in women undergoing intracytoplasmic sperm injection cycles: a randomized controlled trial. J Assist Reprod Genet. 2013 Feb;30(2):239-45. doi: 10.1007/s10815-012-9919-3. Epub 2012 Dec 29. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D006063 | Chorionic Gonadotropin |
| ID | Term |
|---|---|
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| recombinant hCG |
| Drug |
recombinant hCG(500 µg Ovitrell) |
|
| urinary hCG | Drug | 10,000 IU urinary hCG |
|
Evaluation the effect of recombinant hCG on fertilization rate in 1 day after oocyte retrieval
| in 1 day after oocyte retrieval |
| implantation rate | Evaluation the effect of recombinant hCG on implantation rate 4 weeks after embryo transfer | 4 weeks after embryo transfer |
| OHSS occurrence rate will be compared between three groups | Evaluation the effect of recombinant hCG on OHSS occurrence rate will be compared between three groups | from embryo transfer day up to pregnancy test |
| chemical pregnancy rates | Evaluation the effect of recombinant hCG on chemical pregnancy rates 2 weeks after embryo transfer | 2 weeks after embryo transfer |
| clinical pregnancy rates | Evaluation the effect of recombinant hCG on clinical pregnancy rates 4 weeks after embryo transfer | 4 weeks after embryo transfer |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011257 | Pregnancy Proteins |
| D011506 | Proteins |