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| ID | Type | Description | Link |
|---|---|---|---|
| C1353/A12762 | Other Grant/Funding Number | Cancer Research UK |
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| Name | Class |
|---|---|
| Cancer Research UK | OTHER |
| Royal Marsden NHS Foundation Trust | OTHER |
| Cambridge University Hospitals NHS Foundation Trust | OTHER |
| Imperial College Healthcare NHS Trust |
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This project seeks to develop a quantitative imaging biomarker for evaluating and monitoring treatment response in ovarian cancer metastases and assess its potential in monitoring treatment response. This will involve standardising DW-MRI for the abdomen and pelvis across multiple centres and platforms, assessing reproducibility of the measurement in patients planned for neoadjuvant chemotherapy and assessing its utility as an early response biomarker in patients with platinum-sensitive relapse due to receive therapy with carboplatin. Scanning measurements will be correlated with histopathological markers in tumour samples in order to link the biomarker with response mechanisms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Biological validation cohort 1 | |||
| Response assessment cohort 2 |
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| Measure | Description | Time Frame |
|---|---|---|
| Development of a Quantitative Imaging Biomarker for Evaluating Ovarian Cancer Metastases and Assessment of its Potential in Monitoring Treatment Response. | Diffusion-weighted magnetic resonance imaging (DW-MRI) for visualising peritoneal metastases will be developed.Reproducibility will be assessed in a multi-centre setting across multiple vendor platforms and field strengths by comparing 2 baseline scans per person and plotting absolute difference in ADC against mean of the 2 measurements.Biological validation will be achieved by correlating scan data (ADC change) following chemotherapy with histology of the tumour(amount of cell death) at surgery. | 4.0 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with primary or relapsed ovarian cancer
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| Name | Affiliation | Role |
|---|---|---|
| Nandita deSouza, Professor | ICR | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33398064 | Derived | Winfield JM, Wakefield JC, Brenton JD, AbdulJabbar K, Savio A, Freeman S, Pace E, Lutchman-Singh K, Vroobel KM, Yuan Y, Banerjee S, Porta N, Ahmed Raza SE, deSouza NM. Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer: relating MRI changes to tumour cell load and necrosis. Br J Cancer. 2021 Mar;124(6):1130-1137. doi: 10.1038/s41416-020-01217-5. Epub 2021 Jan 4. |
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| ID | Term |
|---|---|
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
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| OTHER |
| Northumbria Healthcare NHS Foundation Trust | OTHER |
| East and North Hertfordshire NHS Trust | OTHER_GOV |
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Tumour samples taken at surgery for histological analysis
| Queen Elizabeth Hospital |
| Newcastle |
| Gateshead |
| NE9 6SX |
| United Kingdom |
| Mount Vernon Cancer Centre | Northwood | Middlesex | HA6 2RN | United Kingdom |
| The Institute of Cancer Research and Royal Marsden NHS Foundation Trust | Sutton | Surrey | SM2 5PT | United Kingdom |
| Singleton Hospital | Swansea | Wales | SA2 8QA | United Kingdom |
| Imperial College Healthcare NHS Trust | London | W6 8RF | United Kingdom |
| D000291 |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |