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| ID | Type | Description | Link |
|---|---|---|---|
| 12BGIA8700001 | Other Grant/Funding Number | American Heart Association |
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FAST-Mag study finished
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| Name | Class |
|---|---|
| University of California, Los Angeles | OTHER |
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This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients. Levels of Magnesium will be measured in the region of infarct in patients who had been treated with intravenous Magnesium therapy following an acute stroke. This study attempts to address whether the traditional intravenous means of neuroprotectant administration achieves adequate concentration of the therapeutic agent in the area of diseased tissue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endovascular Sampling | Experimental | Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations in acute stroke patients undergoing endovascular recanalization who received intravenous Magnesium Sulfate as a part of the FAST-MAG study |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endovascular sampling | Other | Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations: withdrawal of 3ml of blood from vasculature distal to the occlusive thrombus |
| Measure | Description | Time Frame |
|---|---|---|
| Magnesium concentration | The primary endpoint is the relative concentration of Mg in the core cerebral ischemic zone, compared to systemic therapeutic Mg levels, as a measure of delivery efficacy of systemic administration. | intra-procedure (at time of first pass of retrieval device) |
| Measure | Description | Time Frame |
|---|---|---|
| Sampling feasibility | sampling feasibility will be determined by the proportion of cases in which a cerebral circulation Mg level was successfully assayed | intra-procedural (at time of first pass of retrieval device) |
| Safety |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| William J Mack, MD | University of Southern California | Principal Investigator |
| Jeffrey Saver, MD | University of California, Los Angeles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University California Los Angeles: Ronald Reagan and Santa Monica Hospitals | Los Angeles | California | 900094 | United States | ||
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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safety will be assessed by intraoperative adverse events, postoperative neurologic examination including NIH stroke scale, and postoperative brain imaging.
| post-operative day 1 |
| University of Southern California University and LA County Hospitals |
| Los Angeles |
| California |
| 90033 |
| United States |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |