| Primary | Prevalence of SDB in Chronic HF Patients | SDB= Sleep disordered breathing; HF= Heart failure | | Posted | | Count of Participants | | Participants | | 1 night: Patients fulfilling the inclusion and exclusion criteria were examined for sleep-disordered breathing during 1 night in a sleep facility | | | | ID | Title | Description |
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| OG000 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Left Ventricular Ejection Fraction | Amount of blood in the left ventricle at the end of Diastole that is being pumped into the System during systole | | Posted | | Mean | Standard Deviation | % ejection fraction | | 1 night: Patients fulfilling the inclusion and exclusion criteria were examined for LVEF in a medical institution | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Age | | | Posted | | Mean | Standard Deviation | years | | 1-time single assessment at baseline | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Body Mass Index | | | Posted | | Mean | Standard Deviation | kg/m˄2 | | 1-time single assessment at baseline | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Male Gender | | | Posted | | Count of Participants | | Participants | | 1-time single assessment at baseline | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | NYHA Class ≥III | New York Heart Association Class III: Marked Limitation of physical activity. Comfortable at rest, but less than ordinary physical activity results in undue breathlessness, fatigue or palpitations. | | Posted | | Count of Participants | | Participants | | At baseline, the NYHA was determined in a medical institution or taken restrospectively from medical records | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Ischemic Etiology | Ischemic etiology describes a condition where a weakening or disease of the heart muscle is caused by reduced supply of blood (underlying cause might be the coronary artery). Secondary outcome ischemic etiology describes the cause of heart failure (HF) "ischemic" in HF patients without and with sleep-disordered breathing in percent of the respective study arm/group: e.g. x% of patients without SDB have HF with an ischemic etiology. | | Posted | | Count of Participants | | Participants | | 1-time: At baseline the ischemic etiology was determined in the medical institution or taken retrospectively from the medical records. | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Atrial Fibrillation | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline atrial fibrillation (AF) was determined in the medical institution or AF history was taken retrospectively from the medical records | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Nocturnal Dyspnea | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline history of nocturnal dyspnea taken retrospectively from the medical records | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Nocturia ≥3 Times/Night | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline nocturia was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Apnoea-Hypopnea-Index | Number of Apnoeas (cessation of airflow for at least 10 seconds) and hypopneas (reduced airflow for at least 10 seconds) per hours of sleep | | Posted | | Mean | Standard Deviation | events/hour | | 1 night: Apnoea-Hypopnea Index (AHI) was assessed during one night under polysomnography (PSG) in a sleep facility | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Oxygen Desaturation Index | Number of times that arterial blood oxygen saturation Drops by ≥3% from the Basic value. | | Posted | | Mean | Standard Deviation | events/hour | | 1 time: Oxygen desaturation Index (ODI) was assessed during one night under polysomnography (PSG) in a sleep facility | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Mean SpO2 | | | Posted | | Mean | Standard Deviation | %oxygen saturation | | 1 night: oxygen saturation was assessed during one night under polysomnography (PSG) in a sleep facility | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Min SpO2 | Lowest Saturation with oxygen | | Posted | | Mean | Standard Deviation | % oxygen saturation | | 1 night: Minimum saturation with oxygen was assessed during one night under polysomnography (PSG) in a sleep facility | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Medication ACE Inhibitors and/ARBs | ACE: Angiotensin converting Enzyme; ARB Angiotension receptor blocker | | Posted | | Count of Participants | | Participants | | 1-time: At baseline medication was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Beta-blocker | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline medication was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Diuretics | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline medication was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Digitalis | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline medication was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Aldosterone Antagonists | | | Posted | | Count of Participants | | Participants | | 1-time: At baseline medication was assessed 1 time (anamnesis) | | | | ID | Title | Description |
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| OG000 | Chronic HF Without SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) | | OG001 | Chronic HF With SDB | Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15) |
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| Secondary | Male Gender as Predictor for SDB in Chronic HF | From the total number of participants, the number of male patients without and with SDB were counted and an odds Ratio for male sex as predictor for SDB in chronic heart failure | | Posted | | Count of Participants | | Participants | | 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records) | | | | ID | Title | Description |
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| OG000 | Patients With Chronic HF Without SDB Male | patients with chronic heart failure and no sleep disordered breathing who are male | | OG001 | Patients With Chronic Heart Failure and SDB Male | patients with chronic heart failure and sleep disorderd breathing who are male |
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| Secondary | Atrial Fibrillation (AF) as a Predictor for SDB in Chronic HF | From the total number of participants, the number of male patients without and with SDB were counted and an odds ratio calculated for AF as predictor for SDB in chronic heart failure | | Posted | | Count of Participants | | Participants | | 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records) | | | | ID | Title | Description |
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| OG000 | Patients With Chronic HF Without SDB and AF | patients with chronic heart failure and no sleep disordered breathing who have atrial fibrillation (AF) | | OG001 | Patients With Chronic Heart Failure and SDB and AF | patients with chronic heart failure and sleep disorderd breathing who have atrial fibrillation (AF) |
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| Secondary | Ischemic Etiology as Predictor for SDB in Chronic HF | From the total number of participants, the number of male patients without and with SDB were counted and an odds ratio calculated for ischemic etiology as predictor for SDB in chronic heart failure | | Posted | | Count of Participants | | Participants | | 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records) | | | | ID | Title | Description |
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| OG000 | Patients With Chronic HF Without SDB and Ischemic Etiology | patients with chronic heart failure and no sleep disordered breathing who have an ischemic etiology (reduced blood flow to the heart muscle) of HF | | OG001 | Patients With Chronic Heart Failure and SDB and Ischemic Etiol | patients with chronic heart failure and sleep disorderd breathing who have an ischemic etiology (reduced blood flow to the heart muscle) of HF |
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| Secondary | NYHA Class >= III as Predictor for SDB in Chronic HF | From the total number of participants, the number of male patients without and with SDB were counted and an odds ratio calculated for NYHA (New York Heart Association - class I not impaired, class II slighly impaired, class III severly impaired, class IV = unable to perform normal tasks) class≥III as predictor for SDB in chronic heart failure | | Posted | | Count of Participants | | Participants | | 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records) | | | | ID | Title | Description |
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| OG000 | Patients With Chronic HF Without SDB and NYHA>III | patients with chronic heart failure and no sleep disordered breathing who are classified as NYHA >=III | | OG001 | Patients With Chronic Heart Failure and SDB and NYHA >III | patients with chronic heart failure and sleep disorderd breathing who are classified as NYHA >=III |
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