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| ID | Type | Description | Link |
|---|---|---|---|
| COG-AAML12B2 | Other Identifier | Children's Oncology Group | |
| AAML12B2 | Other Identifier | Children's Oncology Group | |
| NCI-2012-00099 | Other Identifier | CTRP (Clinical Trial Reporting Program) |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.
OBJECTIVES:
OUTLINE: Cryopreserved specimens are analyzed for MLL-AF1q fusion protein and AF1 gene expression by mass spectrometry, western blot analysis, semi-quantitative PCR, and qPCR.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gene expression analysis | Genetic | |||
| gene rearrangement analysis | Genetic | |||
| polymerase chain reaction | Genetic | |||
| protein analysis | Genetic | |||
| western blotting | Genetic | |||
| laboratory biomarker analysis | Other | |||
| mass spectrometry | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Subcellular localization of the MLL-AF1q fusion protein in leukemia cells |
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DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Acute myeloid leukemia.
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| Name | Affiliation | Role |
|---|---|---|
| Julie D. Saba, MD, PhD | UCSF Benioff Children's Hospital Oakland | Principal Investigator |
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| ID | Term |
|---|---|
| D007938 | Leukemia |
| D015470 | Leukemia, Myeloid, Acute |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007951 | Leukemia, Myeloid |
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| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D015321 | Gene Rearrangement |
| D016133 | Polymerase Chain Reaction |
| D015153 | Blotting, Western |
| D013058 | Mass Spectrometry |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D055614 | Genetic Phenomena |
| D021141 | Nucleic Acid Amplification Techniques |
| D004586 | Electrophoresis |
| D002623 | Chemistry Techniques, Analytical |
| D055664 | Electrochemical Techniques |
| D015151 | Immunoblotting |
| D007118 | Immunoassay |
| D007158 | Immunologic Techniques |
| D015336 | Molecular Probe Techniques |
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