Photodynamic Therapy for Oral Precursor Lesions

A Randomized Controlled Trial: Photodynamic Treatment for the Therapy of Premalignant Mucosal Oral Lesions.

Pre-malignant lesions are difficult to treat. Even after surgical removal they tend to re-appear. Often the lesions are to large and are apparent on many sites, therefore surgical removal is not always possible. The photodynamic therapy uses a special substance, which is absorbed in cells, and thereafter activated by a defined light. The aim of this study is to compare the photodynamic therapy in potentially malignant lesions to a placebo. The investigators assume a significant better result in photodynamic therapy then treatment with a placebo.

Inclusion Criteria:

• Existing Leukoplakia simplex SIN III (diagnostics by Biopsie)
• Leukoplakia verrucosa without indications of malignant changes (diagnostics by Biopsie)
• Oral Lichen planus SIN III (diagnostics by Biopsie)
• Good mouth hygiene status (tartar, surface)
• Correct seat of the prosthesis and/or the denture
• Located erosions in the oral cavity
• Minimum age:18 years
• Women at the age capable of child-bearing with an appropriate contraception

Exclusion Criteria:

• Malignant changes of the mucous membrane, heavy Dysplasie SIN III, Carcinoma in situ - heavy vitamin deficiency
• Pregnancy
• less than 18
• Satisfying women
• No tobacco abuse
• satisfying therapy with local immunmodulators in lichen ruber
• surgical therapy of leukoplakia indicated