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| Name | Class |
|---|---|
| ImmunoPharma AS | INDUSTRY |
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Examine whether daily oral ingestion of a immunomodulatory mushroom extract (AndoSanTM) in patients with ulcerative colitis (UC) and Crohn's disease (CD), experience clinical, biochemical and genetical improvement in their disease.
A prospective randomised study comparing the mushroom extract with placebo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AndoSan | Active Comparator | AndoSan given to IBD patients |
|
| Sugar extract | Sham Comparator | Sugar extract to IBD patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AndoSan | Dietary Supplement | AndoSan 30 ml x 2 for 21 days |
| |
| Sugar Extract |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction in biochemical blood parameters (pro-inflammatory cytokines) | 21 days |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of calprotectin in feces. | 21 days | |
| Clinical symptom score. | 21 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Egil Johnson, MD. Phd | Ullevaal University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital, Ulleval | Oslo | 0407 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27415795 | Derived | Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288. eCollection 2016. | |
| 26933886 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 6, 2021 | |
| Reset | Jun 1, 2021 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 6, 2021 | Jun 1, 2021 |
| ID | Term |
|---|---|
| D003093 | Colitis, Ulcerative |
| D003424 | Crohn Disease |
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D003092 | Colitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| C579023 | AndoSan |
| D000073893 | Sugars |
| ID | Term |
|---|---|
| D002241 | Carbohydrates |
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| Dietary Supplement |
Sham comparator |
|
| Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Mar 2;11(3):e0150191. doi: 10.1371/journal.pone.0150191. eCollection 2016. |
| D003108 |
| Colonic Diseases |
| D007410 | Intestinal Diseases |