Sinusitis in Children and the Nasopharyngeal Microbiome

My Nose Study: Sinusitis in Children and How Virus Infections Promote Secondary Bacterial Infections

The purpose of this study is to investigate the relationship between viral infections of the upper respiratory tract, perturbations of the nasopharyngeal microbiome in children, and the risk of acute bacterial sinusitis over a one year period. The investigators will determine the incidence of acute bacterial sinusitis post viral upper respiratory infection and identify the viral antecedent infections and other risk factors which predispose to infection and ultimately design strategies to reduce the burden of disease and antimicrobial resistance.

Inclusion Criteria:

• Children 4 to 7 years of age
• Healthy
• English-speaking parent/guardian -

Exclusion Criteria:

• Any underlying condition which would predispose them to the development of sinusitis including congenital or acquired immunodeficiencies
• Craniofacial abnormalities
• Cystic fibrosis
• Allergic rhinitis or a previous episode of chronic sinusitis.