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This study will test the hypothesis that many human heart rhythm disorders are caused by small localized sources, where brief ablation may successfully eliminate the heart rhythm disorder.
The investigators will enroll patients with documented rapid heart rates from the bottom chambers of the heart (ventricular tachyarrhythmias).
During electrophysiological study, the investigators will map the localized sources of these heart rhythm disorders.
All patients will be followed for up to 1 year to ensure that they have no recurrent arrhythmias.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Group | This group will receive brief ablation at localized sources (Focal Impulse and Rotor Modulation, FIRM) | ||
| Control Group | This group receives traditional ablation for this disorder |
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| Measure | Description | Time Frame |
|---|---|---|
| reduction in ventricular tachyarrhythmias events | Using careful clinical monitoring, we will compare the burden of VT/VF after ablation (including FIRM) to the burden preceding ablation. | 3 months |
| safety of ventricular basket mapping in patients undergoing ablation | To assess the incidence of adverse events arising from ablation using basket mapping in the ventricles. These include but are not limited to stroke, systemic thromboembolism, MI or acute coronary syndrome, groin complications, or death. | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
1. Unwillingness or inability to provide informed consent.
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Patients with documented rapid heart rhythms involving the bottom chambers of the heart.
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| Name | Affiliation | Role |
|---|---|---|
| Sanjiv Narayan, MD, PhD | University of California, San Diego | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Diego Medical Center | San Diego | California | United States | |||
| Veterans Affairs San Diego Medical Center |
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| ID | Term |
|---|---|
| D017180 | Tachycardia, Ventricular |
| ID | Term |
|---|---|
| D013610 | Tachycardia |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| San Diego |
| California |
| United States |
| D000075224 |
| Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |