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The investigators study aim is to determine whether there is a any advantage in starting with upper or lower endoscopy. The main study objective will be the amount of analgesia needed for sustaining the examinee's comfort during the exams. Secondary endpoints will rate of detection of significant pathologies, total time of procedure, examinee's tolerance, time to recovery and examinee's satisfaction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| examinees undergoing bidirectional endoscopy | Study population will include sequential examinees undergoing bidirectional endoscopy, age> 18 years |
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| Measure | Description | Time Frame |
|---|---|---|
| Dose of mephridine and midazolam | Dose of analgestices used in order to achive concious sedation | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Time to recovery | Time to full recovery and release after endoscopies | 1 year |
| Rate of significant findings | Rate of significant findings: colonoscopy: polyps, carcinoma, inflammation, diverticuli, A-V malformations Upper endoscopy: Barret's esophagus, severe esophagitis, gastritis, peptic ulcer disease, polyps and space occupying lesions |
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Inclusion Criteria:
Exclusion Criteria:
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Study population will include sequential examinees undergoing bidirectional endoscopy. The decision to perform same day sequential bidirectional endoscopy is of the examinee's caring gastroenterologist, and not part of the study. Only examinees > 18 years will be eligible.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dan Carter, MD | Contact | 972-3-5302197 | carterd@zahav.net.il | |
| Eitan Bardan, MD | Contact | 972-52-6667161 | eitan.bardan@sheba.health.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Dan Carter, MD | Sheba Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheba medical center | Ramat Gan | 55261 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20546443 | Background | Cho JH, Kim JH, Lee YC, Song SY, Lee SK. Comparison of procedural sequences in same-day bidirectional endoscopy without benzodiazepine and propofol sedation: starting at the bottom or the top. J Gastroenterol Hepatol. 2010 May;25(5):899-904. doi: 10.1111/j.1440-1746.2009.06157.x. | |
| 18725159 | Background | Urquhart J, Eisen G, Faigel DO, Mattek N, Holub J, Lieberman DA. A closer look at same-day bidirectional endoscopy. Gastrointest Endosc. 2009 Feb;69(2):271-7. doi: 10.1016/j.gie.2008.04.063. Epub 2008 Aug 23. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 16, 2015 | |
| Reset | Dec 21, 2015 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 16, 2015 | Dec 21, 2015 |
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| 1 year |
| 9448626 | Background | Hardwick RH, Armstrong CP. Synchronous upper and lower gastrointestinal endoscopy is an effective method of investigating iron-deficiency anaemia. Br J Surg. 1997 Dec;84(12):1725-8. |