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Despite spectacular advances since the 90s mechanical ventilation used in intensive care units are amply associated with cardio-respiratory complications: nosocomial pneumonia, lung parenchyma lesions induced by ventilation, hemodynamic instability and ultimately to a significant morbidity and mortality.
NAVA (Neurally Adjusted Assist Ventilation) ventilatory support, provides synchronous support, proportionate to patient's respiratory efforts. More "physiological", this mode would decline its efficacy on patient hemodynamic response. However, to date, no study has focused on hemodynamic impact of NAVA. This is precisely the purpose of NAVADYN11 study, which aims to assess NAVA efficacy on cardiac index in pediatric intensive care unit.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of clinical and biological parameters | Other | Investigation focal lies in hemodynamic monitoring during the last 10 minutes (Cardiac Index Assessment and clinico-biological parameters as: ventilatory and respiratory parameters, NIRS, GDS, Omega Score, heart rate, blood pressure, lactate, BNP, perfusion coefficient…) | ||
| assign optimal ventilatory mode | Other | End of study: At the end of the second session, clinician will assign optimal ventilatory mode regarding patient clinical response. |
| Measure | Description | Time Frame |
|---|---|---|
| Assess the impact of NAVA ventilation on hemodynamic parameters | Assess the impact of NAVA ventilation on hemodynamic parameters in children hospitalized in a Paediatric Intensive Care Unit. Endpoint evaluation consists in a non-invasive measurement of cardiac index by esophageal doppler. |
| Measure | Description | Time Frame |
|---|---|---|
| Omega score | SaO2/SaO2-SvO2 | |
| Heart rate | ||
| Blood pressure |
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Inclusion criteria:
Non inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nicolas JORAM, Doctor | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | 44093 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27821162 | Derived | Liet JM, Barriere F, Gaillard-Le Roux B, Bourgoin P, Legrand A, Joram N. Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study. BMC Pediatr. 2016 Nov 8;16(1):180. doi: 10.1186/s12887-016-0717-4. |
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| NIRS |
| Blood gas |
| Lactate |
| BNP |
| Perfusion score |
| Right cardiac work index | if available |