The predictive scores for gastric cancer in gastric intestinal metaplasia(GIM) patient: a recommendation for Thai population.

Objective:

To evaluate major risk factors for gastric cancer in gastric intestinal metaplasia(GIM) patient in order to propose the appropriate recommendation for Thai people.

Research Design:

Single center, retrospective-cohort study.

Study population and Sample size at Faculty of Medicine, Chulalongkorn University The patients who were diagnosed gastric intestinal metaplasia from 1997 to 2012 and then follow up for 5 years. Estimate sample size =280

• Investigational product, dosage & route of administration
• Questionnaire for explore the risk factors
• EGD with biopsy
• Blood sampling for gastro panel
• Duration of participation
• 5 years or until diagnose gastric cancer

Statistical method:

Unconditional-binary-logistic regression

Inclusion Criteria:

1. All patients were diagnosed GIM
2. All patients have to sign the consent form

Exclusion Criteria:

1. Previous gastric surgery including gastrectomy and bypass surgery
2. Bleeding tendency including decompensated cirrhosis, chronic kidney disease and long-tem antiplatelets or anticoagulants
3. HIV infection
4. History of proton pump inhibitor use within 1 week
5. History of antibiotic use within 4 weeks

All GIM patients in KCMH whose diagnosed from 1997 to 2005, at least 280.