Pain Therapy After Elective Cardiac Surgery

Pharmacokinetic-pharmacodynamic Modeling of the Postoperative Pain Sensation During Patient-controlled Analgesia With Target-controlled Infusion of Hydromorphone, Taking Into Account the Interaction With Intraoperatively Administered Sufentanil for Elective Cardiac Surgery

The purpose of this study is to determine generation of a target controlled infusion model for the patient controlled analgesia with the strong analgesic, hydromorphone, after planned open heart surgery, during which the strong analgesic, sufentanil, was used.

Inclusion Criteria:

• Written informed consent,
• Ability to understand the nature of patient-controlled analgesia and other study-specific procedures,
• Elective cardiac surgery with thoracotomy and subsequent stay in the intensive care unit

Exclusion Criteria:

• Use of MAO inhibitors in the last 14 days,
• Chronic alcoholism or drug addiction in medical history,
• Severe obstructive or restrictive pulmonal disorders in medical history,
• Severe hepatic and renal disorders in medical history,
• Hypothyroidism, pancreatitis in medical history,
• ASA IV,
• Pregnant or nursing females