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| ID | Type | Description | Link |
|---|---|---|---|
| 2011-001925-26 | EudraCT Number |
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The purpose of this study is to determine the impact of curcumin, administrated orally, on iron metabolism in healthy volunteers. Iron metabolism will be describe by hepcidin expression that the investigators observed in vitro and serum hepcidin levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| curcumin | Experimental | oral administration of 6g of curcumin |
|
| placebo | Placebo Comparator | oral administration of 12 sugar pill |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| curcuma longa | Drug | oral administration of 6 grams of curcumin |
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| Measure | Description | Time Frame |
|---|---|---|
| Maximal variation of serum hepcidin level after oral administration of curcumin | within 48 hours after administration of curcumin |
| Measure | Description | Time Frame |
|---|---|---|
| Plasmatic iron bioavailability | Iron, ferritin, transferrin, transferrin saturation | 30min, 1H, 2H, 3H, 4H, 6H, 8H, 12H, 24H et 48H |
| Evaluation of the inhibitory activity of volunteers's serum on hepcidin expression by hepatocytes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre d'Investigation Clinique (CIC) , 2 rue Henri Le Guilloux , CHU Pontchaillou | Rennes | 35000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20169331 | Background | Fatih N, Camberlein E, Island ML, Corlu A, Abgueguen E, Detivaud L, Leroyer P, Brissot P, Loreal O. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med (Berl). 2010 May;88(5):477-86. doi: 10.1007/s00109-009-0588-3. Epub 2010 Feb 19. | |
| 15974953 |
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| ID | Term |
|---|---|
| C012596 | turmeric extract |
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In vitro:
| 30min, 1h, 2h, 3h, 4h, 6h, 8h, 12h, 24h |
| Loreal O, Haziza-Pigeon C, Troadec MB, Detivaud L, Turlin B, Courselaud B, Ilyin G, Brissot P. Hepcidin in iron metabolism. Curr Protein Pept Sci. 2005 Jun;6(3):279-91. doi: 10.2174/1389203054065392. |
| 16946298 | Background | Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007 Jan 1;109(1):353-8. doi: 10.1182/blood-2006-07-033969. Epub 2006 Aug 31. |
| 15501961 | Background | Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ, Steward WP. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004 Oct 15;10(20):6847-54. doi: 10.1158/1078-0432.CCR-04-0744. |
| 18559556 | Background | Vareed SK, Kakarala M, Ruffin MT, Crowell JA, Normolle DP, Djuric Z, Brenner DE. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1411-7. doi: 10.1158/1055-9965.EPI-07-2693. |
| 28370178 | Result | Laine F, Laviolle B, Bardou-Jacquet E, Fatih N, Jezequel C, Collet N, Ropert M, Morcet J, Hamon C, Reymann JM, Loreal O. Curcuma decreases serum hepcidin levels in healthy volunteers: a placebo-controlled, randomized, double-blind, cross-over study. Fundam Clin Pharmacol. 2017 Oct;31(5):567-573. doi: 10.1111/fcp.12288. Epub 2017 May 7. |