Adjuvant Chemotherapy in Patients With Lymph Node Metastasis After Radical Surgery in Cervical Cancer

A Phase II Trial of Adjuvant Chemotherapy in Patients With Lymph Node Metastasis After Radical Surgery in FIGO Stage IA2-IIA Cervical Cancer

Purpose Primary endpoint

• To evaluate the 3-year disease free survival Second endpoints
• To evaluate the 3-year & 5-year overall survival To analyze the toxicity and the quality of life

Inclusion Criteria:

• cervical cancer stage Ia2-IIa
• histology; squamous, adeno, adenosquamous subtype
• age; 20∼70 years
• performance status; GOG 0∼2
• no medical illness
• hematologic, renal, hepatic function; normal
• grossly no residual disease
• histologically confirmed lymph nodes metastases
• no parametrial extension and negative resection margin
• number of retrieved lymph nodes; ≥ 20

Exclusion Criteria:

• patients with grade 2 peripheral neuropathy
• patients with uncontrolled infection