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The aim of this study is to investigate the effects of genetic polymorphisms on pharmacokinetic and pharmacodynamic interactions of clopidogrel and cilostazol in Korean healthy adult volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clopidogrel | Active Comparator | single oral administration of 300mg of clopidogrel |
|
| Cilostarole | Active Comparator | single oral administration of 100mg of cilostazole |
|
| Clopidogrel/Cilostazol | Active Comparator | single oral administration of 300mg clopidogrel and 100mg cilostazol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clopidogrel | Drug | single oral administration of 300mg of clopidogrel |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximum concentration(Cmax), Area under the concentration(AUC), Inhibition of platelet aggregation(IPA) | 9 or 11 point blood sampling according to the interventions | up to 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jae-Gook Shin, MD, PhD | Inje University | Principal Investigator |
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| ID | Term |
|---|---|
| D000077144 | Clopidogrel |
| D000077407 | Cilostazol |
| ID | Term |
|---|---|
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
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| Cilostazol | Drug | single oral administration of 100mg cilostazol |
|
|
| Clopidogrel/Cilostazol | Drug | single oral administration of 300mg clopidogrel and 100mg cilostazol |
|
|
| D009930 |
| Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D013777 | Tetrazoles |
| D001393 | Azoles |
| D011804 | Quinolines |