Climacteric Complains bring to women many problems for living a normal life - hot flashes, irritation are 2 of many problems and the mixture of those 2 plant extract must bring a new horizon for this part of time.

2 herbal extracts used in general alone will be running together for the best climacteric women on quality of life.

The investigators will test the mixture already in the market as GynoPlus and RemifeminPlus, but as each extract has its own particularities the investigators will try CIM/HIP as a unique formulation versus Clifemin® as control and Aplause® as comparator.

This protocol was performed for the best of our volunteers.

Inclusion Criteria:

• Climacteric women 45-60 years old - pre and postmenopausal
• Climacteric complains for at least 3 months
• No treatments for at least 2 months
• MRS score 0.4 or more for at least 3 items
• Hamilton's Scale score from 15-23

Exclusion Criteria:

• Hormon Therapy or any other for the last 3 months
• Antidepressive and Hypnotic medication for the last 3 months
• Sever illness (cardiac, hepatic, renal, digestive or metabolic) or TSH alteration
• History for allergies and hipersensitivity to any component of the drugs formulations
• No knowledge for reading or writing
• Suicide risk