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Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients following lung transplantation. Exercise training has been shown to be a cornerstone of an inpatient rehabilitation program to reduce muscle dysfunction and improve exercise performance. In our study we will investigate the benefit of a whole body vibration training in addition to a standard pulmonary rehabilitation program that includes endurance and strength training. We will include a total of 140 patients (70 patients < 1 year after lung Transplantation and 70 patients > 1 year after lung Transplantation). Our hypothesis is that an addtitional whole body vibration training produces a greater benefit to exercise capacity in lung transplantat patients (LTx).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whole body vibration training | Active Comparator | Whole body vibration training in addition to pulmonary rehabilitation |
|
| No whole body vibration training | No Intervention | Pulmonary rehabilitation without whole body vibration training |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulmonary rehabilitation + whole body vibration training | Other | standard inpatient rehabilitation program including endurance and strength plus squats on a vibration plate for 4x2 minutes, 3 times per week |
| Measure | Description | Time Frame |
|---|---|---|
| change in 6-minute walking distance | change from baseline to day 21 |
| Measure | Description | Time Frame |
|---|---|---|
| change in Wmax | maximum workload in incremental cycling test | change from baseline to day 21 |
| change in Fmax | maximum isometric quadriceps force |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Schön Klinik Berchtesgadener Land | Schönau am Königssee | 83471 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34282853 | Derived | Gutierrez-Arias R, Martinez-Zapata MJ, Gaete-Mahn MC, Osorio D, Bustos L, Melo Tanner J, Hidalgo R, Seron P. Exercise training for adult lung transplant recipients. Cochrane Database Syst Rev. 2021 Jul 20;7(7):CD012307. doi: 10.1002/14651858.CD012307.pub2. |
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| change from baseline to day 21 |
| change in fibre cross sectional area | cross sectional area of the M.rectus femoris, measured by ultrasound | change from baseline to day 21 |
| change in chair rise time | chair rise test: to get from a sitting position to a standing, measuring the time for 5 repetitions | change from baseline to day 21 |
| change in quality of life | SF-36 questionnaire and CRQ questionnaire | change from baseline to day 21 |
| change in body cell mass | measured by bio-impedance analysis | change from baseline to day 21 |
| change in IGF-1 | IGF-1, measured in a blood sample | change from baseline to day 21 |