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| Name | Class |
|---|---|
| Roquette Freres | INDUSTRY |
| Sanders | UNKNOWN |
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This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical density, whose elevation may be beneficial in the prevention of Age-related Macular Degeneration (AMD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rich-eggs | Experimental | subjects consume 2 eggs rich in lutein/zeaxanthin and DHA per day during 4 months |
|
| standard eggs | Active Comparator | subjects consume 2 standard eggs per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nutritional study | Other | subjects consume 2 eggs per day during 4 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in optical density of macular pigment after 4 months of eggs consumption | optical density of macular pigment was measured with a Heidelberg Retinal Angiograph (HRA)specially modify for the measure of the pigment. | before the eggs consumption and four months afterwards |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in lutein and zeaxanthin in plasma and lipoproteins after 4 months of egg consumption | lutein and zeaxanthin were measured by HPLC | before the eggs consumption and four months afterwards |
| change from baseline in fatty acids in plasma and lipoproteins after 4 months of egg consumption |
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Inclusion Criteria:
Exclusion Criteria:
Corrected Visual Acuity <8/10th,
History of cardiovascular disease, specifically coronary heart disease,
Characterized dyslipidemia
* Total cholesterol ³ 2.50 g / L, and / or triglycerides ³ 2.00 g / L
Lipid-lowering treatment,
Current smoking or person who stopped smoking less than 6 months
Cataract or cataract surgery,
Diabetes
Body Mass Index (BMI)> 30 kg/m2,
Taking food supplements in the 3 months preceding the start of the study (carotenoids, omega-3 fatty acids, phytosterols),
Regular consumption in the three months preceding the start of the study products with added phytosterols.
Regular consumption of high fatty fish or shellfish rich in omega-3 (4x a week or more): salmon, sardines, mackerel, herring, trout, tuna, red mullet, sea bass, bream, farmed turbot, mussels, squid / squid, anchovies.
Allergy to eggs
Dieting
Difference significant weight over the last 3 months (> 3 kg)
Inability to understand or adhere to the protocol
Persons deprived of liberty
People in a position to judicial protection
Pregnant Women.
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Michel Lecerf, MD | Institut Pasteur de Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Pasteur de Lille | Lille | 59000 | France |
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| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D009752 | Nutritional Status |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D006304 | Health Status |
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Fatty acids were measured by Gas Chromatography. |
| before the eggs consumption and four months afterwards |
| D003710 | Demography |
| D011154 | Population Characteristics |