Study of Dietary Intervention Under 100 MMOL in Heart Failure

The Long Term Effects of Dietary Sodium Restriction on Clinical Outcomes in Patients With Heart Failure

This study aims to identify the relationship between a low-sodium diet and neurohormonal and clinical status in stable chronic HF patients.

Inclusion Criteria:

• Patients will be recruited from each research center if they are 18 years or older, with confirmed diagnosis of Heart Failure (including both those with a reduced and preserved systolic function), NYHA II-IV, and willing to sign informed consent.

Exclusion Criteria:

• Subjects will be excluded if they have severe hyponatremia (serum sodium <130 mmol/L)
• Renal failure (a glomerular filtration rate < 30 mL/min)
• Uncontrolled thyroid disorders
• Hepatic failure
• Implantable cardiac device (ICD or CRT) or myocardial revascularization procedures (coronary angioplasty and/or surgical revascularization) in the previous 3 months
• Uncontrolled atrial fibrillation or recurrent ventricular arrhythmias
• Malignancy, or with moderate-severe dementia.
• Patients will be excluded if, in the opinion of the investigator, another condition exists that would preclude dietary compliance or compliance with the protocol.