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Central venous catheters are needed in the critical care setting to administer drugs. Three sites are available to gain vascular access: subclavian, internal jugular and femoral. Each site has complications, but there is no randomized controlled study which compared the 3 sites.
The investigators hypothesis is that subclavian catheterization reduces the risk of major complications compared to internal jugular or femoral.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subclavian catheterization | Active Comparator |
| |
| Internal Jugular catheterization | Active Comparator |
| |
| Femoral Catheterization | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Randomization of the site for catheterization | Procedure | Ultra-sound guided insertion strongly recommended |
|
| Measure | Description | Time Frame |
|---|---|---|
| Major complications including catheter-related bloodstream infection | Catheter-related bloodstream infection: (positive catheter-tip quantitative culture plus positive peripheral blood culture(s)) | From central catheter insertion to 48-h after removal |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Jacques Parienti, MD, PhD | University Hospital, Caen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Intensive Care Unit, CHU Caen | Caen | 14000 | France | |||
| Surgical Intensive Care Unit, CHU Caen |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26398070 | Result | Parienti JJ, Mongardon N, Megarbane B, Mira JP, Kalfon P, Gros A, Marque S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D; 3SITES Study Group. Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med. 2015 Sep 24;373(13):1220-9. doi: 10.1056/NEJMoa1500964. | |
| 27311311 |
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| ID | Term |
|---|---|
| D002404 | Catheterization |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| Caen |
| pottier-v@chu-caen.fr |
| France |
| Medical Intensive Care Unit, Cochin, AP-HP | Paris | France |
| Médical Intensive Care Unit, Lariboisière, AP-HP | Paris | France |
| Polyvalent Intensive Care Unit, Mémorial France Etats-Unis | Saint-Lô | France |
| Pages J, Hazera P, Megarbane B, du Cheyron D, Thuong M, Dutheil JJ, Valette X, Fournel F, Mermel LA, Mira JP, Daubin C, Parienti JJ; 3SITES Study Group. Comparison of alcoholic chlorhexidine and povidone-iodine cutaneous antiseptics for the prevention of central venous catheter-related infection: a cohort and quasi-experimental multicenter study. Intensive Care Med. 2016 Sep;42(9):1418-26. doi: 10.1007/s00134-016-4406-4. Epub 2016 Jun 16. |
| 36645531 | Derived | Iachkine J, Buetti N, de Grooth HJ, Briant AR, Mimoz O, Megarbane B, Mira JP, Valette X, Daubin C, du Cheyron D, Mermel LA, Timsit JF, Parienti JJ. Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials. Ann Intensive Care. 2023 Jan 16;13(1):5. doi: 10.1186/s13613-023-01099-9. |
| 35799302 | Derived | Iachkine J, Buetti N, de Grooth HJ, Briant AR, Mimoz O, Megarbane B, Mira JP, Ruckly S, Souweine B, du Cheyron D, Mermel LA, Timsit JF, Parienti JJ. Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials. Crit Care. 2022 Jul 7;26(1):205. doi: 10.1186/s13054-022-04078-x. |