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The investigators previously investigated the cardioprotective effect of an adenosine-lidocaine cardioplegia with moderate-potassium (K+, 10.0 mmol/L) in pediatric cardiac surgery, which was associated with better myocardial protective effects when compared with conventional high-potassium cardioplegia. However, this cardioplegia could not be sucked back into the cardiopulmonary bypass (CPB) circuit because of excessive hemodilution and severe systemic hypotension induced by adenosine. Therefore, the investigators supposed that a moderate-potassium (K+, 10.0 mmol/L) blood cardioplegia without adenosine could also arrest the heart and have better myocardial protective effects compared with conventional hyperkalamic cold blood cardioplegia during cardiac operations without excessive hemodilution and systemic hypotension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MP group | Experimental | Hearts are arrested with cold blood cardioplegia with moderate potassium concentration (K+, 10mmol/L) during cardiac surgery. |
|
| HP group | Active Comparator | Hearts were arrested with cold blood cardioplegia with high potassium concentration (K+, 20mmol/L) during cardiac operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MP (moderate potassium) group | Drug | Hearts were arrested with cold blood cardioplegia with moderate potassium concentration (K+, 10mmol/L)during cardiac operation |
|
| Measure | Description | Time Frame |
|---|---|---|
| post-operative Serum cTnI concentration decreased significantly in 24hours | myocardial injury could be sensitively reflected by post operative Serum cTnI concentration. | 24h after myocardial reperfusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zhenxiao Jin, PhD | Department of Cardiovascular Surgery, Xijing Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiovascular Surgery, Xijing Hospital | Xi'an | Shaanxi | 710032 | China |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Aug 19, 2012 | |
| Reset | Sep 17, 2012 | |
| Release | Sep 28, 2012 | |
| Reset | Oct 29, 2012 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Aug 19, 2012 | Sep 17, 2012 | |||
| Sep 28, 2012 |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| ID | Term |
|---|---|
| D044382 | Population Groups |
| ID | Term |
|---|---|
| D003710 | Demography |
| D011154 | Population Characteristics |
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|
| HP (High potassium) group | Drug | Hearts are arrested with cold blood cardioplegia with high potassium concentration (K+, 20mmol/L)during cardiac operation. |
|
|
| Oct 29, 2012 |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |