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The aim of this study is the comparison between the effects of supplementation with omega-3 or placebo for 10 weeks in type 2 diabetics
Adipose tissue is recognized as an important endocrine organ in human. Not only it has function of storing unlimited energy but also its secretory roles is subject to intense research in recent years. Acylation stimulating protein(ASP), Retinol-binding protein 4 (RBP4) and lipocalin-2 (LCN2) are circulating adipokines elevated in diabetes. C5L2 is a G-protein-coupled receptor. activation of C5L2 by ASP, has been shown. Fatty acids may influence the expression of adipokines. Epidemiological studies showed that omega-3 reduce the development of insulin resistance and diabetes. Because fatty acids are the main component of adipose tissue, it is essential interest to clarify the biological effects of omega-3 on the expression of relevant adipokines.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| diabetes, omega-3 | Active Comparator | patient with type 2 diabetes who receive 4gr/day omega-3 |
|
| placebo, diabetes | Placebo Comparator | patient with type 2 diabetes who receive 4 cap of placebo/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| omega-3 | Dietary Supplement | 4 cap 1 gr omega-3 per day for 10 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| serum total cholesterol | change from baseline at 10 weeks | |
| serum High-density lipoprotein (HDL) cholesterol | change from baseline at 10 weeks | |
| serum Low-density lipoprotein (LDL) cholesterol | change from baseline at 10 weeks | |
| serum triglycerides (TG) level | change from baseline at 10 weeks | |
| postprandial triglycerides | change from baseline at 10 weeks | |
| complete blood count(CBC) | change from baseline at 10 weeks | |
| fasting plasma glucose(FPG) | change from baseline at 10 weeks | |
| Glycated hemoglobin (Hb A1c) | change from baseline at 10 weeks | |
| acylation stimulating protein (ASP) | change from baseline at 10 weeks | |
| lipocalin-2 (LCN2) | change from baseline at 10 weeks | |
| Retinol-binding protein 4 (RBP4) | change from baseline at 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| gene expression of C5L2 | change from baseline at 10 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tehran University of Medical Sciences | Tehran | Tehran Province | Iran |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Dec 10, 2013 | |
| Reset | Jan 29, 2014 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Dec 10, 2013 | Jan 29, 2014 |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
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| placebo | Dietary Supplement | patient with type 2 diabetes who receive 4 cap placebo/day for 10 weeks |
|
| non-esterified fatty acids (NEFA) | change from baseline at 10 weeks |
| insulin | change from baseline at 10 weeks |
| postprandial ASP | chage from baseline at 10 weeks |
| D004700 | Endocrine System Diseases |
| D008055 |
| Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |