The Impact of Omega-3 Supplementation on Gene Expression in Type 2 Diabetics

The Impact of Omega-3 Supplementation on Acylation Stimulating Protein(ASP), Retinol-binding Protein 4 (RBP4) and Lipocalin-2 (LCN2) Gene Expression of ASP Receptor (C5L2) in WBC of Patient With Diabetes Type 2

The aim of this study is the comparison between the effects of supplementation with omega-3 or placebo for 10 weeks in type 2 diabetics

Adipose tissue is recognized as an important endocrine organ in human. Not only it has function of storing unlimited energy but also its secretory roles is subject to intense research in recent years. Acylation stimulating protein(ASP), Retinol-binding protein 4 (RBP4) and lipocalin-2 (LCN2) are circulating adipokines elevated in diabetes. C5L2 is a G-protein-coupled receptor. activation of C5L2 by ASP, has been shown. Fatty acids may influence the expression of adipokines. Epidemiological studies showed that omega-3 reduce the development of insulin resistance and diabetes. Because fatty acids are the main component of adipose tissue, it is essential interest to clarify the biological effects of omega-3 on the expression of relevant adipokines.

Inclusion Criteria:

• literate
• Willingness to participation
• Diabetic patients 30-65 years old
• Body mass index in the range 18.5-40
• Avoidance of dietary supplements
• vitamins and herbal products at least 2 weeks before and throughout the intervention

Exclusion Criteria:

• people who have used omega-3 supplements in last 3 months
• Having chronic renal disease
• hepatic disease
• gastrointestinal disease
• hematological disorders
• hypothyroidism or hyperthyroidism
• Treatment with Orlistat or sibutramine for weight loss
• Pregnancy and lactation
• Treatment with insulin or Thiazolidinediones