Comparative of Effects of Sublingual Misoprostol and Infusion Oxytocin in Reduction of Bleeding at Cesarean

Phase 2-3 Study of Comparative of Effects of Sublingual Misoprostol and Infusion Oxytocin in Reduction of Blood Loss at Cesarean Deliveries

The purpose of this study is to determine whether the effect of sublingual misoprostol is better than infusion oxytocin in reduction of blood loss at cesarean deliveries.

A total of 180 pregnant women with gestational age 37 weeks and over who underwent cesarean operation in Imam Reza hospital had elective or emergency procedure with incision in lower segment during one year recruitment. The patients were randomly assigned to undergo 200 micrograms misoprostol sublingual or 400 micrograms and infusion 20 unit oxytocin after spinal anesthesia. Main outcome measures: The length of surgery, bleeding volume, the need for transfusion, fever, tachycardia, and hypotension.

Inclusion Criteria:

• Indication of Cesarean Deliveries
• Elective or Emergency with Incision in Lower Segment in Women with
• Gestational Age more than 37 Weeks.

Exclusion Criteria:

• Anemia
• Multiple Pregnancy
• Polyhydraminus
• Prolonged Labor
• Premature Rupture of Membrane and Patients had Previous History of Diabetes Mellitus
• Hypertension
• Cardiovascular Disease
• Coagulopathy Disease