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| Name | Class |
|---|---|
| Politecnico di Milano | OTHER |
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The aim of this study is to examine chest wall volume changes monitored by opto-electronic plethysmography during recovery from anesthesia and early postoperative period.
This is prospective, randomized clinical trial in subjects undergoing elective surgery requiring general anesthesia.
Opto-electronic plethysmography (OEP) has been developed as a non-invasive method for the analysis of chest wall motion, allowing highly accurate measurements of chest wall volume changes of different respiratory compartments in various conditions.
The investigators set out to use this technology to study chest wall volume changes during recovery from total intravenous anesthesia (from discontinuing the anesthetic agent till extubation) and early postoperative period.
The study protocol compares two different approaches:
The volume changes of the chest wall is monitored continuously by OEP, functional residual capacity (FRC) and arterial oxygenation are measured at the defined points in the protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| open lung | Active Comparator | The lung recruitment maneuver (RM) immediately after intubation using pressure controlled ventilation, increase in peak inspiratory pressure up to 30 cm H2O during tidal ventilation, respiratory rate 4/min and positive end expiratory pressure (PEEP) 15 cm H20. PEEP 7 cm H2O until extubation. Inspiratory oxygen concentration (FiO2) 40% during recovery from anesthesia. |
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| control | No Intervention | No recruitment maneuver is performed. PEEP 0 cm H2O. Inspiratory oxygen concentration (FiO2) 100 % during recovery from anesthesia. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lung recruitment maneuver | Procedure | RM: peak inspiratory pressure 30 cmH2O, PEEP 15 cm H20 FiO2 0,4 (from end of surgery till extubation) |
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| Measure | Description | Time Frame |
|---|---|---|
| Opto-electronic plethysmography (OEP) | Respiratory movements and thoracic and abdominal volume changes is recorded continuously using OEP (OEP system, BTS,Milan, Italy) by analysing the movements of retro-reflective markers using six video cameras connected to an automatic optoelectronic motion analyser. | 1. 5 min after each of these steps: the onset of the mechanical ventilation, the randomization, the end of the surgery 2. continuously during recovery 3. one hour after extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Functional residual capacity (FRC) | 5 min after each of these steps: the onset of mechanical ventilation, the randomization, the end of the sergery | |
| Oxygenation (paO2) | Arterial blood gas measurement. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Frykholm | Uppsala University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University Hospital, Anesthesia and Intensive care dep. | Uppsala | Uppsala County | 751 85 | Sweden |
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| 5 min after each of these steps: the onset of mechanical ventilation, the randomization, the end of the surgery, extubation |