The purpose of this study is to determine whether Gastropyloric Complex Capsules are safe and effective in the treatment of chronic atrophic gastritis (CAG).

Till now, there is no ideal treatment to chronic atrophic gastritis(CAG). This study is try to find a possible treatment to CAG with Gastropyloric Complex Capsules.

Inclusion Criteria:

• Age 18-70 years, male or female
• Histologically diagnosed CAG
• HP negative confirmed by gastric mucosal staining
• Signed an written informed consent

Exclusion Criteria:

• CAG with high-grade intraepithelial neoplasia
• Severe gastric mucosal erosion or bleeding needing treatment
• Active peptic ulcer, GERD, or esophageal stricture
• History of upper GI tract surgery
• History of malignant diseases
• With depression, anxiety neuroses, or hysteria
• Heart failure (NYHA class lll or lV), liver disease (ALT ≥ 80 IU/L, AST ≥ 80 IU/L) or renal disease(Cr ≥ 150 ummol/L)
• Uncontrolled hypertension
• Uncontrolled diabetes
• Alcohol abuse
• Drug allergy
• Participated in another investigational study within 4 weeks prior to Visit 0
• Pregnancy, be a nursing mother or without conception control
• There is any concern by the investigator regarding the safe participation of the participant in the study or for any other reason; the investigator considers the participant inappropriate for participation in the study