Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique

Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique

The purpose of this study is to determine feasibility of pleural biopsies with the cryoprobe during semirigid thoracoscopy. The secondary aim is to evaluate safety with focus on bleeding intensity.

The primary aim of this study is to determine feasibility of pleural biopsies with the cryoprobe during semirigid thoracoscopy. We will assess size, morphological features, immunohistochemistry and diagnostic yield as measures of the quality of the samples. The secondary aim is to evaluate safety with focus on bleeding intensity.

Inclusion Criteria:

• 18 or more years old
• Unilateral pleural effusion of unknown origin
• Pleural irregularities suspicious for pleural malignancy
• Referral for thoracoscopy after less invasive means of diagnosis had failed

Exclusion Criteria:

• Uncontrolled bleeding tendency
• Unstable cardiovascular status
• Severe heart failure
• ECOG performance status 4
• Persistent hypoxemia after evacuation of pleural fluid
• Pleural symphisis, fibrothorax