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Progenitor limbo sclerocorneal cells have properties of proliferation and differentiation to corneal and conjunctival epithelium. This cells can be isolated and ex vivo expanded using cell culture technics that could permit the biological replacement of damaged ocular surface.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Progenitor Autologous Cells | Experimental | Progenitor Autologous Cells of Sclerocorneal Limbus Amplified ex Vivo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biological replacement corneal surface | Procedure | the expanded tissue will be applied to patient to replace the damaged ocular surface |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Acuity | visual acuity improvement | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in appearance of ocular surface | presence of corneal epithelium de novo | 6 months |
| lack of scar tissue in ocular surface | 6 months |
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principal Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo P Casaroli Marano, MD PhD | Hospital Clinic of Barcelona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto Universitario Barraquer | Barcelona | Barcelona | 08021 | Spain | ||
| Instituto de Microcirugía Ocular |
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| decrease of preexisting corneal vascularization | 6 months |
| Improvement of corneal transparency | 6 months |
| absence or decrease of corneal conjunctivalization | the amount of caliciform cells using impression cytology will be compare between screening and 6 months visit | 6 months |
| adverse events | 6 months |
| Barcelona |
| Barcelona |
| 08035 |
| Spain |
| Hospital Clinic of Barcelona | Barcelona | Barcelona | 08036 | Spain |