The purpose of this study is to evaluate new biomarkers for patients presenting to a physician for surgery to remove a mass in their pelvis and to continue to evaluate these types of patients using the ROMA algorithm for post-market benefits.

Inclusion Criteria:

• Female, age 18 years or older
• Adnexal mass present documented by imaging
• Scheduled to undergo surgery based on a finding of adnexal mass
• Able and willing to provide Informed Consent

Exclusion Criteria:

• Previous history of ovarian cancer
• Previous history of bilateral oophorectomy
• Currently known to be pregnant
• Unable to provide informed consent

Women with an adnexal mass, presenting to a general surgeon or obstetrician/ gynecologist at a general or specialty center within the United States, for whom a decision to proceed with surgery to remove the mass has been made.