Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets

The purpose of this study is to measure the area under the curve (AUC0-48h; extent of systemic availability) and the maxi-mum concentrations (Cmax) of total serum levothyroxine (TT4, bound and free fraction) after a single pharmacological dose of 600 μg administered as tablets also containing iodine supple-ments vs. the same dose of levothyroxine administered as a reference solution without iodine.

Inclusion Criteria:

• Euthyroid men
• Age: 18 - 50
• Normal values for fT4 und TSH
• Good state of health

Exclusion Criteria:

• Thyroid function disorders in terms of subclinical or overt hyper- or hypothyroidism
• History of thyroid function disorders
• Focal or diffuse autonomies of the thyroid gland
• Thyroid nodules >1 ml according to sonographic examination
• Any acute or chronic illness
• Dermatitis herpetiformis