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The purpose of this study is to compare the diagnostic efficacy of two follow-up schedules for the early detection of cancers in the population under study on cancer incidence at 3 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard arm | No Intervention | standard follow-up | |
| Intensive follow-up | Experimental | Standard follow-up plus whole body MRI at inclusion, one and two years |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| whole body MRI | Other | whole body MRI at inclusion, one and two years |
|
| Measure | Description | Time Frame |
|---|---|---|
| cancer incidence | cancer incidence during the first 3 years | 3 years |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Gustave Roussy | Villejuif | 94805 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28772306 | Derived | Caron O, Frebourg T, Benusiglio PR, Foulon S, Brugieres L. Lung Adenocarcinoma as Part of the Li-Fraumeni Syndrome Spectrum: Preliminary Data of the LIFSCREEN Randomized Clinical Trial. JAMA Oncol. 2017 Dec 1;3(12):1736-1737. doi: 10.1001/jamaoncol.2017.1358. |
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| ID | Term |
|---|---|
| D016864 | Li-Fraumeni Syndrome |
| ID | Term |
|---|---|
| D009386 | Neoplastic Syndromes, Hereditary |
| D009369 | Neoplasms |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| D049914 | DNA Repair-Deficiency Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |