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Colonoscopy is currently most effective procedure used for detecting colon cancer especially in the early stages. Screening colonoscopies are performed in the symptom-free patients at risk of familial colon cancer. During colonoscopy air commonly used to insufflate the bowel may be retained after the procedure causing pain and discomfort to the patients. One of the methods used to reduce pain and discomfort is insufflation of carbon dioxide (CO2) instead of air during colonoscopy.
Aim of the study is evaluation of the use of carbon dioxide insufflation during colonoscopy.
The study was conducted in 200 consecutive patients undergoing screening colonoscopies for the detection of early colon cancer. The examinations were performed with Olympus 165 colonoscopes by seven experienced endoscopists, each of whom performed alone about over 2000 colonoscopies. The patients were randomly assigned to Group I and II with either air or carbon dioxide insufflation. Both study groups were matched by sex, age, duration of the procedure, and BMI. The authors compared for the duration of the procedure, coecal intubation time, complication rate, pulse rates immediately after the procedure, 15 minutes after, and subjective pain evaluation on a Visual Analogue Scale.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carbon dioxide | Experimental | Patients insufflated with carbon dioxide during screening colonoscopy |
|
| Air | Active Comparator | Patients insufflated with air during screening colonoscopy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colonoscopy | Procedure | Screening colonoscopy |
|
| Measure | Description | Time Frame |
|---|---|---|
| duration of procedure | Time from introduction of a colonoscope to removal of the colonoscope. | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| coecal intubation time | Time from introduction of a colonoscope to intubation of the coecumo | 1 hour |
| pain immediately after the procedure | Pain assessed by VAS scale immediately after colonoscopy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Miroslaw Szura, MD PhD | I Dept of General, Oncological and GI Surgery Jagiellonian University | Study Director |
| Radoslaw Pach, MD PhD | I Dept of General, Oncological and GI Surgery Jagiellonian University | Principal Investigator |
| Andrzej Matyja, MD PhD | I Dept of General, Oncological and GI Surgery Jagiellonian University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 1st Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University | Cracow | Malopolska | 31-501 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24915135 | Result | Szura M, Pach R, Matyja A, Kulig J. Carbon dioxide insufflation during screening unsedated colonoscopy: a randomised clinical trial. Eur J Cancer Prev. 2015 Jan;24(1):37-43. doi: 10.1097/CEJ.0000000000000047. |
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| ID | Term |
|---|---|
| D011127 | Polyps |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003113 | Colonoscopy |
| D004724 | Endoscopy |
| ID | Term |
|---|---|
| D016099 | Endoscopy, Gastrointestinal |
| D016145 | Endoscopy, Digestive System |
| D003938 | Diagnostic Techniques, Digestive System |
| D019937 | Diagnostic Techniques and Procedures |
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| 1 min |
| pain 15 minutes after colonoscopy | Pain assessed by VAS scale 15 minutes after colonoscopy | 15 min |
| complication rate | any compication of screening colonoscopy | 24 hours |
| D003933 | Diagnosis |
| D003949 | Diagnostic Techniques, Surgical |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |