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| Name | Class |
|---|---|
| Kantonsspital Aarau | OTHER |
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Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH.
Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia.
Design: Prospective observational study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hospitalized patients | hospitalized patients with hyponatremia |
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| Measure | Description | Time Frame |
|---|---|---|
| diagnostic accuracy of copeptin within hospital stay | diagnostic accuracy will be determined by receiver operated curve (ROC) analysis. The study is powered to detect a difference of copeptin levels between patients with partial central diabetes insipidus (DI) and patients with primary polydipsia. | participants will be followed for up to 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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hospitalized patients with severe hypo or hypernatremia
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| Name | Affiliation | Role |
|---|---|---|
| Mirjam Christ-Crain, MD, PhD | University Hospital, Basel, Switzerland | Principal Investigator |
| Beat Müller, MD | Kantonsspital Aarau, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mirjam Christ-Crain | Basel | Basel | 4031 | Switzerland | ||
| Beat Müller |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30462243 | Derived | Sailer CO, Winzeler B, Nigro N, Bernasconi L, Mueller B, Christ-Crain M. Influence of Outdoor Temperature and Relative Humidity on Incidence and Etiology of Hyponatremia. J Clin Endocrinol Metab. 2019 Apr 1;104(4):1304-1312. doi: 10.1210/jc.2018-01507. | |
| 29422070 | Derived | Nigro N, Winzeler B, Suter-Widmer I, Schuetz P, Arici B, Bally M, Refardt J, Betz M, Gashi G, Urwyler SA, Burget L, Blum CA, Bock A, Huber A, Muller B, Christ-Crain M. Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the "Co-MED study". Crit Care. 2018 Feb 9;22(1):33. doi: 10.1186/s13054-018-1955-7. |
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| ID | Term |
|---|---|
| D007010 | Hyponatremia |
| D006955 | Hypernatremia |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Aarau |
| Canton of Aargau |
| Switzerland |