A Study of Onartuzumab (MetMAb) in Combination With Tarceva (Erlotinib) in Participants With Met Diagnostic-Positive Non-Small Cell Lung Cancer... | NCT01456325 | Trialant

A Study of Onartuzumab (MetMAb) in Combination With Tarceva (Erlotinib) in Participants With Met Diagnostic-Positive Non-Small Cell Lung Cancer... | NCT01456325 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Adult participants, greater than or equal to (>/=) 18 years of age

Eastern Cooperative Oncology Group (ECOG) performance status 0-1

Histologically or cytologically confirmed incurable Stage IIIb/IV NSCLC tumor

Met diagnostic-positive status tested by immunohistochemistry (IHC)

Results of endothelial growth factor receptor (EGFR)-activating mutation testing

Radiographic evidence of disease

Prior treatment with at least one platinum-based line of treatment (for stage IIIb/IV) and no more than one additional line of chemotherapy treatment; the last dose of chemotherapy must have been administered >/= 21 days prior to Day 1

availability of tissue sample for diagnostic testing is required

Exclusion Criteria:

More than 30 days of exposure to an investigational or marketed agent that can act by EGFR inhibition, or a known EGFR-related toxicity resulting in dose modifications (EGFR inhibitors including but not limited to gefitinib, erlotinib and cetuximab)

Brain metastases or spinal cord compression not definitively treated with surgery and/or radiation, or previously treated central nervous system (CNS) metastases or spinal cord compression without evidence of stable disease for >/= 14 days

History of another malignancy in the previous 3 years, unless cured by surgery alone and continuously disease free for at least 3 years; participants with prior history of non-invasive cancers are eligible

Inadequate hematological, biochemical or organ function

Significant history of cardiac disease

Serious active infection at time of randomization or other serious underlying medical conditions that would impair the ability of the participant to receive protocol treatment

Any inflammatory changes of the surface of the eye

Clinically significant gastro-intestinal disease, including uncontrolled inflammatory gastro-intestinal diseases

Pregnant or lactating women

Positive for human immunodefinciency (HIV) infection

-

Chandler, Arizona 85224, United States

-

Hayward, California 94545, United States

-

Modesto, California 95355, United States

-

Oakland, California 94611, United States

-

Orange, California 92868, United States

-

Roseville, California 95661, United States

-

Sacramento, California 95817, United States

-

Sacramento, California 95825, United States

-

San Diego, California 92108, United States

-

San Francisco, California 94115, United States

-

San Jose, California 95119, United States

-

Santa Clara, California 95051, United States

-

South San Francisco, California 94080, United States

-

Vallejo, California 94589, United States

-

Walnut Creek, California 94596, United States

-

Boca Raton, Florida 33486, United States

-

Clearwater, Florida 33761, United States

-

Fort Myers, Florida 33901, United States

-

Jacksonville, Florida 32207, United States

-

Jacksonville, Florida 32256, United States

-

Chicago, Illinois 60637, United States

-

Urbana, Illinois 61801, United States

-

Bettendorf, Iowa 52722, United States

-

Sioux City, Iowa 51101, United States

-

Louisville, Kentucky 40207, United States

-

Annapolis, Maryland 21401, United States

-

Baltimore, Maryland 21201, United States

-

Baltimore, Maryland 21231, United States

-

Baltimore, Maryland 21237, United States

-

Boston, Massachusetts 02114, United States

-

Boston, Massachusetts 02115, United States

-

Springfield, Massachusetts 01107, United States

-

Ann Arbor, Michigan 48106, United States

-

Duluth, Minnesota 55805, United States

-

St Louis, Missouri 63110, United States

-

Omaha, Nebraska 68114, United States

-

Reno, Nevada 89502, United States

-

Farmington, New Mexico 87401, United States

-

Syracuse, New York 13210, United States

-

Chapel Hill, North Carolina 27514, United States

-

Canton, Ohio 44718, United States

-

Cleveland, Ohio 44106, United States

-

Columbus, Ohio 43210, United States

-

Columbus, Ohio 43219, United States

-

Philadelphia, Pennsylvania 19104, United States

-

Pittsburgh, Pennsylvania 15232, United States

-

Charleston, South Carolina 29403, United States

-

Columbia, South Carolina 29210, United States

-

Chattanooga, Tennessee 37404, United States

-

Knoxville, Tennessee 37909, United States

-

Nashville, Tennessee 37203, United States

-

Dallas, Texas 75390, United States

-

Fort Worth, Texas 76104, United States

-

Houston, Texas 77030, United States

-

Bristol, Virginia 24201, United States

-

Roanoke, Virginia 24014, United States

-

La Plata, B1900BAJ, Argentina

-

Quilmes, 1878, Argentina

-

Santa Fe, S3000FFU, Argentina

-

Camperdown, New South Wales 2050, Australia

-

Waratah, New South Wales 2298, Australia

-

Chermside, Queensland 4032, Australia

-

Adelaide, South Australia 5041, Australia

-

Parkville, Victoria 3050, Australia

-

Brussels, 1200, Belgium

-

Ghent, 9000, Belgium

-

Gilly (Charleroi), 6000, Belgium

-

Liège, 4000, Belgium

-

Namur, 5000, Belgium

-

Salvador/BA, Estado de Bahia 41820-021, Brazil

-

Lajeado, Rio Grande do Sul 95900-000, Brazil

-

Novo Hamburgo, Rio Grande do Sul 93510-250, Brazil

-

Jaú, São Paulo 17210-080, Brazil

-

São Paulo, São Paulo 08270-070, Brazil

-

Sorocaba, São Paulo 18030-005, Brazil

-

Saint John, New Brunswick E2L 4L2, Canada

-

Sault Ste. Marie, Ontario P6A 2C4, Canada

-

Toronto, Ontario M4N 3M5, Canada

-

Toronto, Ontario M5G 2M9, Canada

-

Montreal, Quebec H3A 1A1, Canada

-

Montreal, Quebec J4B 5Z7, Canada

-

Santiago, 0, Chile

-

Santiago, Providencia, Chile

-

Temuco, 4810469, Chile

-

Čakovec, 40000, Croatia

-

Dubrovnik, 20000, Croatia

-

Pula, 52100, Croatia

-

Zagreb, 10000, Croatia

-

Besançon, 25030, France

-

Caen, 14076, France

-

Grenoble, 38 043, France

-

Limoges, 87042, France

-

Marseille, 13915, France

-

Montpellier, 34295, France

-

Paris, 75970, France

-

Poitiers, 86021, France

-

Saint-Herblain, 44805, France

-

Suresnes, 92151, France

-

Vandœuvre-lès-Nancy, 54511, France

-

Bad Berka, 99437, Germany

-

Berlin, 14165, Germany

-

Großhansdorf, 22927, Germany

-

Hamburg, 21075, Germany

-

Heidelberg, 69126, Germany

-

Karlsruhe, 76137, Germany

-

Mainz, 55131, Germany

-

München, 80336, Germany

-

Oldenburg, 26121, Germany

-

Regensburg, 93053, Germany

-

Ulm, 89081, Germany

-

Villingen-Schwenningen, 78052, Germany

-

Pokfulam, Hong Kong

-

Shatin, Hong Kong

-

Edelény, 3780, Hungary

-

Miskolc, 3529, Hungary

-

Szombathely, 9700, Hungary

-

Cork, Ireland

-

Dublin, 8, Ireland

-

Beersheba, 8410101, Israel

-

Haifa, 4959381, Israel

-

Jerusalem, 91120-01, Israel

-

Jerusalem, 9372212, Israel

-

Kfar Saba, 4428164, Israel

-

Petah Tikva, 49100, Israel

-

Ramat Gan, 5262100, Israel

-

Rehovot, 76100, Israel

-

Aviano, Friuli Venezia Giulia 33081, Italy

-

Genoa, Liguria 16132, Italy

-

Milan, Lombardy 20141, Italy

-

Monza, Lombardy 20900, Italy

-

Rozzano, Lombardy 20089, Italy

-

Orbassano, Piedmont 10043, Italy

-

Ancona, The Marches 60121, Italy

-

Lido di Camaiore, Tuscany 55043, Italy

-

Perugia, Umbria 06123, Italy

-

Aichi, 464-8681, Japan

-

Chiba, 277-8577, Japan

-

Ehime, 791-0280, Japan

-

Fukuoka, 811-1395, Japan

-

Fukuoka, 812-8582, Japan

-

Hyōgo, 650-0047, Japan

-

Hyōgo, 673-8553, Japan

-

Kanagawa, 236-0051, Japan

-

Kyoto, 606-8507, Japan

-

Miyagi, 980-8574, Japan

-

Miyagi, 981-1293, Japan

-

Okayama, 700-8558, Japan

-

Okayama, 710-8602, Japan

-

Osaka, 534-0021, Japan

-

Osaka, 537-8511, Japan

-

Osaka, 589-8511, Japan

-

Osaka, 591-8555, Japan

-

Saitama, 362-0806, Japan

-

Shizuoka, 411-8777, Japan

-

Tokyo, 104-0045, Japan

-

Tokyo, 113-8677, Japan

-

Tokyo, 135-8550, Japan

-

Tokyo, 160-0023, Japan

-

Tokyo, 173-8605, Japan

-

Yamaguchi, 755-0241, Japan

-

Amsterdam, 1081 HV, Netherlands

-

Groningen, 9700 RB, Netherlands

-

Maastricht, 6229 HX, Netherlands

-

Lima, L27, Peru

-

Lima, Lima 1, Peru

-

Lima, Lima 27, Peru

-

Gdansk, 80-952, Poland

-

Krakow, 31-531, Poland

-

Lodz, 93-509, Poland

-

Olsztyn, 10-357, Poland

-

Poznan, Poland

-

Ivanovo, 153040, Russia

-

Krasnodar, 350040, Russia

-

Omsk, 644013, Russia

-

Saint Petersburg, 189646, Russia

-

Saint Petersburg, 197022, Russia

-

Saint Petersburg, 197101, Russia

-

Tomsk, 634050, Russia

-

Belgrade, 11000, Serbia

-

Belgrade, 11080, Serbia

-

Kragujevac, 34000, Serbia

-

Bloemfontein, 9301, South Africa

-

Johannesburg, 2193, South Africa

-

Sandton, 2196, South Africa

-

Gyeonggi-do, 443-380, South Korea

-

Seoul, 05505, South Korea

-

Seoul, 06591, South Korea

-

Seoul, 120-752, South Korea

-

Barcelona, Barcelona 08035, Spain

-

Barcelona, Barcelona 08036, Spain

-

Barcelona, Barcelona 08041, Spain

-

Barcelona, Barcelona 08916, Spain

-

Sabadell, Barcelona 08208, Spain

-

Madrid, Madrid 28007, Spain

-

Madrid, Madrid 28034, Spain

-

Madrid, Madrid 28050, Spain

-

Madrid, Madrid 28222, Spain

-

Seville, Sevilla 41013, Spain

-

Valencia, Valencia 41014, Spain

-

Changhua, 500, Taiwan

-

Kaohsiung City, 813, Taiwan

-

Taipei, 100, Taiwan

-

Cherkassy, 18009, Ukraine

-

Chernivtsi, 58013, Ukraine

-

Dnipropetrovsk, 49102, Ukraine

-

Sumy, 40005, Ukraine

-

Zaporizhzhya, 69040, Ukraine

-

Belfast, BT9 7AB, United Kingdom

-

Grimsby, DN33 2BA, United Kingdom

-

Leicester, LE1 5WW, United Kingdom

-

London, SE1 9RT, United Kingdom

-

London, SW10 9NH, United Kingdom

-

Manchester, M2O 4BX, United Kingdom