Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)

The present study aims to elucidate if there is a metabolomic profile alteration in the embryos of obese women in order to understand if the reduced implantation rate observed in these patients is directly related to this factor. Furthermore, the investigators seek to establish if there is any difference between obese women with Polycystic Ovary Syndrome (PCO) and without PCO. The investigators compare these metabolomic profile embryos with embryos of egg-donation programme.

Inclusion Criteria:

• BMI > 30 kg/m2
• Age < 38 years old
• Non smokers
• First IVF cycle (groups 2 & 3, not Control group)
• Normal uterus (seen by ultrasound)
• normal basal hormonal profile(FSH,LH,estradiol,testosterone,androstenedione, insulin, SHBG, glucose, AMH)
• Antral follicle count(> 5 FA for each ovary)
• Menses every 25-35 days.

Exclusion Criteria:

• < 5 or > 20 oocytes retrieved after stimulation cycle
• estradiol >3000 pg/ml or progesterone > 1,5 ng/ml on the hCG day.
• < 2 evolutive embryos in the culture medium.