A Study of MM-121 With Paclitaxel in Platinum Resistant/ Refractory Advanced Ovarian Cancers

A Phase II Randomized Open Label Study of MM-121 in Combination With Paclitaxel Versus Paclitaxel Alone in Patients With Platinum Resistant/ Refractory Advanced Ovarian Cancers

To determine whether the combination of MM-121 plus paclitaxel is more effective than paclitaxel alone

This is a multicenter, open-label, randomized, Phase II study of MM-121 in patients with platinum resistant or refractory recurrent/advanced ovarian cancers. Up to 210 patients will be randomized (2:1) to receive MM-121 plus paclitaxel or paclitaxel alone.

Inclusion Criteria:

• Locally advanced/metastatic or recurrent epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer
• Received at least one prior platinum based chemotherapy regimen
• Platinum-resistant or refractory
• Eligible for weekly paclitaxel
• Adequate liver and kidney function
• 18 years of age or above

Exclusion Criteria:

• Evidence of any other active malignancy
• History of severe allergic reactions to paclitaxel or other drugs formulated in Cremophor®EL