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| ID | Type | Description | Link |
|---|---|---|---|
| AEMPS no.04-0013 | Other Identifier | Spanish Medicines Agency (identification number) | |
| 5R01DA017987 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this study are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MDMA | Experimental | One single dose of MDMA (1.5 mg/kg; range 75-100 mg) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MDMA | Drug | One single dose of MDMA ( 1.5 mg/kg; range: 75-100 mg) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentrations of dextromethorphan in plasma and urine. | Blood samples and urine to determine dextromethorphan and dextrorphan concentrations until 240h. | 240 hours after MDMA dosing. |
| Concentrations of caffeine in plasma and urine. | Blood samples and urine to determine caffeine and theobromine concentrations until 240h. | 24 hours after MDMA dosing. |
| Concentrations of MDMA and metabolites (influence of gender) | Determination of MDMA and metabolites concentrations in plasma and urine during 48h. Influence of gender male/female. | 48h after MDMA administration. |
| Concentrations of MDMA and metabolites (influence of genetics) | Determination of MDMA and metabolites concentrations in plasma and urine during 48h. Influence of gene polymorphisms of CYP2D6, CYP3A4, COMT, SERT. | 48h after MDMA administration. |
| Measure | Description | Time Frame |
|---|---|---|
| Effects of MDMA on physiological response. | Effects of MDMA on blood preassure, heart rate, temperature, pupil diameter, esophoria. Influence of gender and genetic polymorphisms. | 24h |
| Effects of MDMA on physiological response. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Magà Farre, PhD | IMIM-Hospital del Mar (Institut de Recerca Hospital del Mar) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IMIM-Hospital del Mar (Institut de Recerca Hospital del Mar) | Barcelona | Barcelona | 08003 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21456632 | Result | Yubero-Lahoz S, Pardo R, Farre M, O'Mahony B, Torrens M, Mustata C, Perez-Mana C, Carbo ML, de la Torre R. Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. Clin Pharmacokinet. 2011 May;50(5):319-29. doi: 10.2165/11584550-000000000-00000. | |
| 18794647 | Result | O'Mathuna B, Farre M, Rostami-Hodjegan A, Yang J, Cuyas E, Torrens M, Pardo R, Abanades S, Maluf S, Tucker GT, de la Torre R. The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans. J Clin Psychopharmacol. 2008 Oct;28(5):523-9. doi: 10.1097/JCP.0b013e318184ff6e. |
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| ID | Term |
|---|---|
| D003075 | Coitus |
| ID | Term |
|---|---|
| D012725 | Sexual Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine |
| ID | Term |
|---|---|
| D000662 | Amphetamines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D000588 | Amines |
| D009930 |
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Effects of MDMA on subjective effects (feelings of intoxication, euphoria, bad effects etc) and psychological tests (VESSPA, ARCI). Influence of gender and genetic polymorphisms.
| 24h |
| 23112822 | Derived | Pardo-Lozano R, Farre M, Yubero-Lahoz S, O'Mathuna B, Torrens M, Mustata C, Perez-Mana C, Langohr K, Cuyas E, Carbo Ml, de la Torre R. Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): the influence of gender and genetics (CYP2D6, COMT, 5-HTT). PLoS One. 2012;7(10):e47599. doi: 10.1371/journal.pone.0047599. Epub 2012 Oct 24. |
| Organic Chemicals |