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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
| Bispebjerg Hospital | OTHER |
| Danish Parkinson Association | OTHER |
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The purpose of this study is (1) to provide quantitative information of the motor manifestations of Parkinson's disease and (2) to quantify the effect of high intensive antigravity locomotor exercise or Deep Brain Stimulation implantations in Parkinson's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deep Brain Stimulation | Experimental |
| |
| Locomotor Exercise | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensive antigravity locomotor exercise | Other | High intensive antigravity locomotor exercise, 3 sessions/week, for 8 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Isometric Tremor Approximate Entropy | Approximate Entropy is a metric. When used to quantify isometric tremor irregularity, information of dominant/pathological CNS oscillators can be obtained. | Change from baseline up to 16 weeks |
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Inclusion Criteria (exercise arm):
Inclusion Criteria (Deep Brain Stimulation arm):
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martin H Rose, MSci | Department of Exercise and Sport Sciences, University of Copenhagen | Principal Investigator |
| Bente R Jensen, MSci, PhD | Department of Exercise and Sport Sciences, University of Copenhagen | Study Chair |
| Stig Sonne-Holm, MD, DSc | Department of Orthopedic Surgery, Hvidovre University Hospital | Study Chair |
| Annemette Løkkegaard, MD, PhD | Department of Neurology, Bispebjerg University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | 2650 | Denmark |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| Deep Brain Stimulation | Procedure | Deep Brain Stimulation implantation |
|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |