Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 14/2553 | Other Grant/Funding Number | Thammasat research grant |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate whether buffered hypertonic saline (BHS) is superior to normal saline (NSS) for improving mucociliary function and relief nasal symptoms in children with allergic rhinitis.
BHS is superior to NSS for improving mucociliary function that by measure saccharine clearance time(SCT)at 10 minute after nasal irrigation compare to baseline.
BHS is superior to NSS for clinical effectiveness at short period and 1 month follow up
at short period: compare the following results at baseline and 10 minute after nasal irrigation
at 2 and 4 weeks follow up : compare the following results at baseline and 10 minute after nasal irrigation
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NSS irrigation salt | Active Comparator |
| |
| BHS nasal irrigaiton salt | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NSS nasal irrigation salt | Drug | nasal irrigation twice daily for 4 weeks period |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change from baseline in SCT at 10 minute after nasal irrigation of BHS and NSS | SCT method : subjects seated with their head upright. A rhinoprobe was used to place a small piece of saccharine on the medial aspect of the inferior turbinate approximately 1 cm, posterior to the nasal vestibule. The SCT was recorded as the subject's first perception of a sweet taste. | baseline, 10 minute after nasal irrigaiton |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of BHS and NSS on clinical effectiveness | evaluate total nasal symptom score, side effect, satisfaction for nasal irrigation, quality of life at 1st visit, 2nd week and 4 week follow up | 1st visit, 2nd week and 4 week follow up |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Araya Satdhabudh, MD | Thammasat University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Araya Satdabudha | Klong Luang | Pratumthanee | 12120 | Thailand |
Not provided
| ID | Term |
|---|---|
| D065631 | Rhinitis, Allergic |
| ID | Term |
|---|---|
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| BHS nasal irrigation salt | Drug | nasal irrigation twice daily for 4 weeks period |
|
|
| D010038 |
| Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |