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| Name | Class |
|---|---|
| University Hospital, Caen | OTHER |
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The main objective of this study is to validate the utility of IgE anti-cetuximab in the treatment strategy to identify patients at risk for a severe allergic reaction to cetuximab (grade 3 or 4 of the classification of NCI) and thus reduce the incidence of severe reactions.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample | Other | The IgE anti cetuximab test will then be conducted by an ELISA test |
| Measure | Description | Time Frame |
|---|---|---|
| Validate the utility of an IgE anti-cetuximab test in the treatment strategy | We hypothesize that a positive specific IgE assay predicts the occurrence of an allergic reaction during the first dose of cetuximab. Thus, in population areas where the prevalence of specific IgE positive plasma is higher, the use of alternative therapies in patients with a positive test would reduce the incidence of anaphylactic reactions to cetuximab. If the use of specific IgE anti-cetuximab in the treatment strategy is effective, there will be reduction in the incidence of anaphylaxis to cetuximab in the participating centers. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with colon cancer or upper aero-digestive tract and candidates for treatment with cetuximab
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| Name | Affiliation | Role |
|---|---|---|
| GERVAIS Radj, MD | Centre François Baclesse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU | Amiens | 80054 | France | |||
| Centre hospitalier |
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| Bayeux |
| 14400 |
| France |
| CHU | Caen | 14033 | France |
| Centre François Baclesse | Caen | 14076 | France |
| Centre Georges-François Leclerc | Dijon | 21079 | France |
| Centre Oscar Lambret | Lille | 59020 | France |
| CHRU Lille | Lille | 59037 | France |
| CHU Charles Nicolle | Rouen | 76000 | France |
| Centre Henri Becquerel | Rouen | 76038 | France |
| Centre Paul Strauss | Strasbourg | 67065 | France |
| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D006967 | Hypersensitivity |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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