The purpose of this study is to determine the analgesic efficacy and safety of N1539 in subjects undergoing abdominal laparoscopic surgery.

Inclusion Criteria:

• Planning to undergo elective abdominal laparoscopic surgery involving a single site/organ and does not have intraperitoneal metastases suspected or identified

Exclusion Criteria:

• Use of ketorolac is contraindicated
• Use of general anesthesia is contraindicated
• Has a medical condition that could adversely impact subject participation
• Has diabetes mellitus and glycosylated hemoglobin (HbA1c) >9.5 or history of prolonged uncontrolled diabetes
• Body mass index (BMI) less than 18 or greater than 35
• Has a history of intolerance or allergic reactions to non-steroidal anti-inflammatory drugs (NSAIDs), Cox-2 inhibitors, aspirin or other salicylates
• Known or suspected sleep apnea
• History of Hepatitis B or C
• Has a psychiatric disorder that impairs capability of subject to report pain
• Known to have chronic obstructive pulmonary disease (COPD) with carbon dioxide retention or chronic hypoxemia