Safety and Tolerability of BVS857 in Subjects With Insulin Resistance

A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Parenterally Administered BVS857 in Healthy Subjects Without and With Insulin Resistance

The study will assess the safety, tolerability, drug label and effect in subjects with and without insulin resistance.

Inclusion Criteria:

• Healthy male and female subjects with insulin resistance
• Subjects with controlled hypertension and hyperlipidemia

Exclusion Criteria:

• Smokers
• History of drug or alcohol use
• Autonomic dysfunction
• Significant illness or cardiovascular disease
• Immunodeficiency disease

Other protocol-defined inclusion/exclusion criteria may apply