Detection of Helicobacter Pylori Infection by High Resolution Endoscopy

Detection of Helicobacter Pylori Infection by Non-magnifying High Resolution Endoscopy is Possible Within the Gastric Corpus

Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone. Most studies concluded that it is not possible to diagnose H. pylori-related gastritis on the basis of endoscopic findings. However, the resolution power of endoscopy has greatly improved in recent years and the exact examination of gastric mucosa was possible.

Our study aimed to achieve the following: (1) describe the H. pylori-related mucosal pattern in the gastric corpus using high-definition endoscopy; (2) evaluate the diagnostic accuracy for H. pylori detection; (3) find the optimal biopsy site for rapid urease test (RUT); (4) validate the inter- and intraobserver agreement in the assessment of endoscopic patterns.

Inclusion Criteria:

• Patients who underwent upper endoscopy

Exclusion Criteria:

• Age < 20 or > 70
• Severe systemic disease or advanced chronic liver disease
• Medication history of NSAID, PPI, H2 blockers or antibiotics
• History of H. pylori eradication therapy
• History of gastric surgery
• Recent history of upper GI bleeding
• Gastric or duodenal ulcer (including old scar change) during endoscopy
• Anemia (Hemoglobin level < 10mg/dL)
• Pangastritis