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| Name | Class |
|---|---|
| The Ministry of Science, Technology and Innovation, Denmark | OTHER_GOV |
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The purpose of the meal study is to investigate acute effects on satiety and inflammation of advanced glycation endproducts (AGE) in healthy overweight subjects. The AGE content of the meal is affected by food preparation methods: frying/grilling versus boiling/steaming.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low AGE meal | Experimental | Test meal prepared by boiling/steaming the food |
|
| High AGE meal | Experimental | Test meal prepared by frying/grilling the food |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary meal intervention | Other | Test meals with different AGE content made by different cooking methods |
|
| Measure | Description | Time Frame |
|---|---|---|
| Appetite sensation | Appetite sensation measured by visual analogue scales | Every 30 min up to 5 hours after test meal |
| Plasma ghrelin | Continuous measurement up to 5 hours after test meal | |
| Plasma GLP-1 | Continuous measurements up to 5 hours after test meal | |
| Plasma PYY | Continuous measurements up to 5 hours after test meal | |
| Plasma insulin | Continuous measurements up to 5 hours after test meal | |
| Plasma glucose | Continuous measurements up to 5 hours after test meal | |
| Urine AGE | From 24 hour before to 48 hour after test meal |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma triglycerides | Continuous measurements up to 5 hours after test meal | |
| Expression of genes related to AGE | Continuous measurements up to 24 hours after test meal | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susanne G Bügel | Department of Human Nutrition, University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Human Nutrition, University of Copenhagen | Copenhagen | Frederiksberg C | 1958 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23929260 | Derived | Poulsen MW, Bak MJ, Andersen JM, Monosik R, Giraudi-Futin AC, Holst JJ, Nielsen J, Lauritzen L, Larsen LH, Bugel S, Dragsted LO. Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. Eur J Nutr. 2014;53(2):661-72. doi: 10.1007/s00394-013-0574-y. Epub 2013 Aug 9. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D003924 | Diabetes Mellitus, Type 2 |
| D007333 | Insulin Resistance |
| D002318 | Cardiovascular Diseases |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| IL-1 beta |
| Continuous measurements up to 5 hours after test meal |
| IL-6 | Continuous measurements up to 5 hours after test meal |
| TNF-alpha | Continuous measurements up to 5 hours after test meal |
| CRP | Continuous measurements up to 5 hours after test meal |
| VCAM | Continuous measurements up to 5 hours after test meal |
| ICAM | Continuous measurements up to 5 hours after test meal |
| MIF | Continuous measurements up to 5 hours after test meal |
| Plasma AGE | Continuous measurements up to 48 hours after test meal |
| Urine isoprostanes | From 24 hour before to 24 hours after test meal |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |
| D010335 | Pathologic Processes |